Wenzhou City People's Hospital

Genotype Distribution Characteristics and Short-Term Follow-Up of HPV Infection Among Male Outpatients in Wenzhou, China

Objective: The aim of this study was to investigate the genotype distribution, co-infection patterns, and disease-specific characteristics of human papillomavirus (HPV) infection among male outpatients in Wenzhou, China. Methods: A total of 1934 male outpatients who underwent HPV...

Calcitriol Promotes Keratinocyte Differentiation and Barrier-Associated Protein Expression: Potential Involvement of Cav1-Related Calcium Signaling

Background: Skin barrier dysfunction is closely associated with impaired keratinocyte differentiation. Calcitriol helps maintain the stable state of the epidermis, but the role of caveolin-1 (Cav1)-associated calcium signaling in calcitriol-induced skin barrier-associated respons...

Pulmonary Tropheryma whipplei infection in a patient with systemic lupus erythematosus: diagnosis supported by BALF tNGS with subsequent doxycycline-based treatment: a case report

Whipple’s disease is a rare systemic infection caused by Tropheryma whipplei ( T. whipplei ). Pulmonary involvement is uncommon and may mimic sarcoidosis, tuberculosis, or malignancy, delaying diagnosis. Pulmonary presentations may be atypical and nonspecific. We report the case...

Impact of dynamic blood glucose trajectories on mortality in critically ill non-traumatic intracranial hemorrhage patients: a retrospective cohort study

Dysglycemia is frequently observed in patients with non-traumatic intracranial hemorrhage (ICH) and has been linked to adverse clinical outcomes. However, the prognostic impact of longitudinal blood glucose trajectories in critically ill non-traumatic intracranial hemorrhage rema...

Diagnostic criteria for sarcopenia (EWGSOP2, AWGS2, SDOC) and their prognostic value: a systematic review and meta-analysis of prevalence, all-cause mortality, and hospitalisation

Three current consensus definitions for sarcopenia—EWGSOP2 (2019), AWGS2 (2019), and SDOC (2020)—differ substantially in their conceptual framework and operational cutoffs. No published meta-analysis has quantitatively pooled prognostic estimates across all three criteria. We aim...

Puerarin‐Loaded Macrophage‐Derived Exosomes for Experimental Atherosclerosis

ABSTRACT Atherosclerotic cardiovascular disease (AS) remains a leading global health concern. In this study, we investigated a macrophage‐derived exosome‐based delivery system for puerarin (Pue). The isolated vesicles were characterized by transmission electron microscopy, partic...

Impact of carotenoids on body composition and adipokine hormones: a systematic review and meta-analysis of randomized controlled trials

Carotenoids, a class of antioxidant phytochemicals, have been proposed to influence adiposity and metabolic regulation through modulation of oxidative stress, inflammation, and adipokine secretion. However, clinical evidence remains inconsistent. This systematic review and meta-a...