Wellcome/MRC Institute of Metabolic Science

Molecular mechanisms underlying the effectiveness of triiodothyroacetic acid (Triac) in patients with resistance to thyroid hormone β (RTHβ): a multicentre, international, retrospective cohort study

Background Disease features in resistance to thyroid hormone beta (RTHβ), caused by THRB mutations, arise from insensitivity to thyroid hormone in tissues expressing thyroid hormone receptor (TR)β and from lifelong thyrotoxic effects in TRα1-expressing tissues, posing substantial...

Data-driven identification of small molecules inducing brown adipocyte activation and differentiation

Promoting the recruitment and function of human brown adipose tissue (BAT) holds significant promise for preventing and treating obesity and related metabolic complications. While identifying genes to enhance BAT recruitment and thermogenic activation is crucial, traditional upre...

Rapid Whole Genome Sequencing Enhances Pediatric Cancer Diagnosis

Abstract Whole-genome sequencing (WGS) has been shown to improve diagnosis beyond standard-of-care genetic tests and guide precision treatment for childhood cancer. While WGS is now offered for children with suspected cancer in England, clinical workflows typically return results...

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling

Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid...

Exploring the impact of recipe boxes on dietary quality and food agency: a pilot and feasibility randomized controlled trial in households with school-aged children

Abstract Background Preparing and consuming food at home is associated with healthier diets. Recipe box subscriptions may support meal preparation at home while improving dietary quality and cooking skills, reducing time-poverty, and facilitating family cohesion. We are conductin...

Implementing and upscaling pregnancy and postpartum physical activity: a workgroup report from the international society of behavioral nutrition and physical activity — from individual-level barriers to multilevel implementation and scale-up

Abstract Background Physical activity during pregnancy and the postpartum period is important for maternal health, yet participation remains suboptimal, and the implementation and scale-up of physical activity initiatives across diverse cultural and health-system contexts remain...

Latent paths in mode choice models: incorporating street-level environment features for active travel policy

There is growing empirical evidence that walking and cycling are influenced by street-level environment features such as greenness and traffic stress. To assess active travel policy, these features are increasingly incorporated into mode choice models through predictors that aggr...

Factors Associated With Progression From Level 1 to Level 2 Sensor‐Detected Hypoglycaemia in People With Type 1 and Insulin‐Treated Type 2 Diabetes: A Post Hoc Analysis From the Hypo‐ METRICS Study

ABSTRACT Aims We investigated the proportion of sensor‐detected hypoglycaemic (SDH) events progressing to level 2, and associated variables. Materials and Methods We used data from Hypo‐METRICS, which recruited people with type 1 (pwT1D) and insulin‐treated type 2 diabetes (pwT2D...