Wellcome Centre for Infectious Diseases Research in Africa

Molecular detection of respiratory viruses from breath samples: Evaluation of nucleic acid extraction systems and PCR panels

Background Reliable and scalable molecular testing is essential for risk assessment and monitoring of respiratory viruses with epidemic or pandemic potential. The AveloMask Kit (Avelo) is a non-invasive sampling device that collects exhaled breath aerosols (XBA) using a high-perf...

Exhaled breath aerosol sampling for detection of pulmonary tuberculosis in adults: a study protocol for an exploratory diagnostic accuracy study

Introduction Tuberculosis remains a major global health challenge, causing over one million deaths annually. Current diagnostic techniques depend on restrictive sputum sampling. Better sampling methods are needed to enable early detection and effective management. This study intr...

Immunohistochemical detection of high-risk human papillomavirus E6/E7 oncoproteins is associated with aggressive clinicopathological features in prostate cancer: a Sudanese cohort study

Abstract Background The role of human papillomavirus (HPV) in prostate cancer development remains uncertain, despite accumulating evidence of a potential link in certain populations. While HPV is a known cause of several epithelial cancers, its connection to prostate cancer (PCa)...