Weill Cornell Medical College in Qatar

Severe ulcerative colitis flare precipitating Guillain–Barré syndrome: a case report and literature review

Abstract Introduction Ulcerative colitis (UC) is a chronic inflammatory bowel disease that can occasionally be accompanied by extraintestinal manifestations, though neurological involvement is very rare. Guillain–Barré Syndrome (GBS), an acute immune-mediated polyradiculoneuropat...

Gene–Environment Interaction Mendelian Randomization Reveals Statin-Dependent Associations Between Metabolites and Lipid Traits

Introduction/Background: Observational links between circulating metabolites and lipid traits are often confounded by environmental factors. This study applied Mendelian randomization (MR) and gene–environment interaction MR (MR-G×E) to assess the average causal effects of geneti...

Global Variation in Fusion Assessment Practices Following Anterior Cervical Discectomy and Fusion

Study DesignCross-sectional survey.ObjectivesTo characterize global variation in imaging modalities, fusion criteria, and decision-making practices for assessing fusion following anterior cervical discectomy and fusion (ACDF).MethodsA modified 30-item survey using Delphi-informed...

Screening of Attention-Deficit Hyperactivity Disorder and its associated factors among medical university students in Lebanon: A multicenter cross-sectional study

Attention-Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder that may adversely affect academic performance and well-being. Data on ADHD among Lebanese medical students are limited. This study assessed the prevalence of probable ADHD symptoms and associ...

The Proteinase Activated Receptor-2 mediates Protective Immunity in Early Experimental Leishmaniasis

Resistance to Leishmania (L.) major depends on the development of a L. major-specific Th1 response, while Th2 differentiation results in susceptibility. We previously showed that the early microenvironment of infected skin delivers important signals for T cell differentiation. We...

The Effect of Microbiome‐Modulating Therapeutics on Anthropometric and Hemodynamic Biomarkers in Metabolic Syndrome: A Systematic Review, Meta‐Analysis, and Meta‐Regression of Clinical Trials

ABSTRACT Background Metabolic syndrome (MetS) is a prevalent cardiometabolic disorder characterized by central obesity, insulin resistance, dyslipidemia, and hypertension. Microbiome‐targeted therapies with probiotics, prebiotics, and synbiotics may improve outcomes by modulating...

Targeting Overweight and Obesity Phenotypes for Secondary Prevention of Cardiovascular Disease: A Call to Action for the Middle East and Beyond

ABSTRACT Although there are conflicting clinical data on the efficacy of weight reduction in reducing secondary events in patients with comorbid overweight and obesity (OAO) and cardiovascular disease (CVD), there is excellent epidemiological and biological evidence of a cause–ef...

Standard Antiplatelet Therapy Versus Thrombolysis in Acute Spontaneous Spinal Cord Infarction: A Propensity Score–Matched Analysis

BACKGROUND: Spinal cord infarction (SCI) is a rare stroke subtype with no established acute treatment guidelines. Thrombolytic therapy has been used empirically based on extrapolation from cerebral stroke protocols, but comparative effectiveness data are lacking. We compared outc...

Environmental and genetic interactions in autism spectrum disorder: a literature review with a focus on air pollution

Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental condition which is associated with complex interactions between genetic susceptibility and environmental exposures. More recently, air pollution has been investigated as a modifiable risk factor and contributor to th...