Weifang People's Hospital

Endovascular treatment guided by tissue window rather than time window may be safe and feasible in patients with ischemic stroke

For progressive stroke caused by large vessel occlusion (LVO) beyond the 24-hour time window, dedicated evidence for endovascular treatment (EVT) remains scarce, and there is currently no established treatment standard. We investigated the safety and feasibility of tissue window-...

Harnessing hydrogel technology for advanced periodontitis therapy: A multifunctional approach to oral health restoration

Periodontitis is a bacterially driven inflammatory disease that can lead to tooth mobility and tooth loss. Conventional non-surgical therapy, antibiotics, and surgery may be limited by residual subgingival biofilms, antimicrobial resistance, and variable clinical outcomes. This r...

Moldavoside ameliorates hypertension and autoantibodies targeting the angiotensin II type 1 receptor-induced endothelial damage via regulation of RhoE/CAV-1/eNOS axis

Globally, more than 100 million patients with resistant hypertension experience severe endothelial damage. Therefore, exploring the mechanisms underlying endothelial damage and developing effective interventions is urgently required. The clinical data and biochemical indicators o...

Exploring the potential role of ADRB1 as a suppressor gene and prognostic biomarker in lung adenocarcinoma: a comprehensive bioinformatics analysis

Lung adenocarcinoma (LUAD) is the most common pathological subtype of lung cancer. Sympathetic activation remodels the tumor microenvironment through β-adrenergic receptors (β-ARs) and is associated with malignant progression. Research mainly focuses on β 2 -AR, while the role of...

Mismatch between quality and engagement in myasthenia gravis–related videos: a cross-sectional study on Chinese social media platforms

As short-video platforms increasingly play a prominent role in disseminating public health information in China, evaluating the quality of their health-related content is crucial. This study aims to systematically assess the quality, reliability, and content characteristics of vi...

Association between USP6NL polymorphisms and Parkinson’s disease in Northern Chinese Han population: a case-control study

The pathogenesis and progression of Parkinson’s disease (PD) are closely associated with impaired membrane trafficking. As a key regulator of membrane trafficking, this study examined the association between two USP6NL polymorphisms (rs61844597 and rs73569171) and PD risk in the...

KneeFusionNet Enables Accurate and Efficient Comprehensive Detection of Knee Ligament Injuries on Magnetic Resonance Imaging: A Multicenter Validation Study

Purpose To develop and externally validate KneeFusionNet, a multimodal deep learning model for detecting anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), medial collateral ligament (MCL), and lateral collateral ligament (LCL) injuries on knee magnetic resonanc...

Cervical small-cell neuroendocrine carcinoma mixed with squamous cell carcinoma first suspected on liquid-based cytology and confirmed by biopsy: a case report

Cervical small cell neuroendocrine carcinoma (SCNEC) admixed with squamous cell carcinoma (SCC) is a rare malignancy associated with a poor prognosis. While histological features of this mixed tumor have been described, liquid-based cytology (LBC) findings remain largely undocume...

Dynamic multimodal brain function monitoring enables quantitative severity grading and prognostic prediction in pediatric neurocritical care

OBJECTIVE: Multimodal Brain Function Monitoring (MBFM) enables simultaneous assessment of cerebral blood flow, intracranial pressure (ICP), and brain tissue oxygenation, providing dynamic evaluation for pediatric neurocritical care. This study evaluated MBFM-derived parameters, i...

Clinical Efficacy of Neoadjuvant Camrelizumab Plus Chemotherapy for Triple‐Negative Breast Cancer and Tumor Immune Microenvironment Analysis: A Prospective‐Retrospective Cohort Study

ABSTRACT The impact of immune checkpoint inhibitors combined with neoadjuvant chemotherapy (NAC) on surgical outcomes and immune remodeling remains underexplored. To investigate the efficacy and tumor immune microenvironment (TIME) changes of camrelizumab plus NAC for triple‐nega...

Tea and cognitive health in aging: Current evidence and future directions

The health benefits of tea drinking have been extensively studied, and in the past 20 years, there has been increasing interest in the role of tea drinking in promoting cognitive health among older adults. This review aims to analyze existing evidence on the benefits of tea drink...

Fructose induces PERK-dependent ER stress and mitochondrial dysfunction via nucleotide depletion in clear cell renal cell carcinoma

Abstract Clear cell renal cell carcinoma (ccRCC) exhibits a paradoxical fructose metabolism signature characterized by upregulation of the fructose transporter GLUT5 alongside downregulation of the catabolic enzymes (ketohexokinase, aldolase B, and triokinase), a pattern associat...

Lycium barbarum glycopeptide attenuates ischaemic stroke by inhibiting inflammation via SIRT3-mediated NLRP3 deacetylation

Background Inflammatory processes play a critical role in ischaemic stroke. Acetylation of NLRP3 is a key step in amplifying neuroinflammation. (LbGP), a bioactive glycoprotein derived from Lycium barbarum, has anti-inflammatory potential, but its mechanisms in post-stroke neuroi...