Washington State University

Resampling Fragility, Perturbation Fragility, and Why the Global Fragility Index Is Not a P-Value in Disguise

The charge that the fragility index is a P-value in disguise rests on a strong correlation between the two across trials, and it overlooks a distinction between two distinct constructs derived from the same observed result. Resampling fragility asks how often the significance ver...

Material Characterization of Lignin‐Filled Polypropylene Composites

ABSTRACT Lignin, an environmentally friendly byproduct from pulping and biorefinery processes, was incorporated into polypropylene (PP) as ground and spray‐dried powders. The effects of lignin morphology, particle size, and loading on the mechanical, rheological, viscoelastic, an...

Implementable and Sustainable Upcycling of Medical Plastic Waste to Liquid Highly Branched Alkanes via Tandem Catalytic Cracking-Hydrogenation Strategy

Abstract Recalcitrant plastic waste (RPW) poses a significant environmental and health challenge due to its persistent nature and potential contamination with toxic chemicals and biohazards. Upcycling RPW containing mixed polyolefins, contaminants, and additives often struggles t...

The role of CYP3A-CYP2E1 interactions in activation of CYP3A enzymes by chronic alcohol exposure

To examine the effect of chronic alcohol exposure on the activity of CYP3A enzymes in human liver, we studied the metabolism of CYP3A-specific substrates 7-benzyloxyquinoline (7-BQ) and ivermectin in 23 preparations of human liver microsomes (HLM) obtained from donors with docume...

Maternal Obesity Disrupts Trophoblast Differentiation and Causes Female-Specific Labyrinth Defects in the Mouse Placenta

Maternal obesity (MO) alters the intrauterine environment and increases the risk of a variety of developmental outcomes; however, the effects on placental cell population and development remain unclear. In this study, we investigated the impact of MO on placental cellular composi...