Walter Reed National Military Medical Center

Fronto-Parietal Brain Metabolites Following Traumatic Brain Injury—A Proton MR Spectroscopy Study

Background: Conventional structural CT and MRI may be normal after mild traumatic brain injury (mTBI), while magnetic resonance spectroscopic imaging (1H-MRSI) can provide regional measures of brain metabolites. We examined supracallosal fronto-parietal metabolite ratios in activ...

Histology resolved proteomic characterization of the triple negative breast cancer tumor immune microenvironment

Treatment options for the highly aggressive triple-negative breast cancer (TNBC) subtype remain limited, though the immune microenvironment represents a promising therapeutic target. We conducted a histology resolved tumor microenvironment analysis of TNBC by employing deep quant...

Rotator Cuff Tears Part I: Diagnosis, Nonoperative Management, and Repair of Posterosuperior Tears—An International Expert Consensus Statement

PURPOSE: To establish updated international consensus statements on the diagnosis, nonoperative management, and repair of posterosuperior rotator cuff tears, reflecting new evidence, evolving techniques, and ongoing areas of controversy. METHODS: A consensus process on the treatm...

Rotator Cuff Tears Part II: Subscapularis Repair, Augmentation, and Tendon Transfer—An International Expert Consensus Statement

PURPOSE: To establish updated international consensus statements on subscapularis repair, graft/patch augmentation and superior capsular reconstruction, and tendon transfers for rotator cuff tears, reflecting new evidence, evolving techniques, and ongoing areas of controversy. ME...

Developmental eye movement test performance and oculomotor dysfunction in adults with chronic mild traumatic brain injury

PURPOSE: Oculomotor dysfunction is common after mild traumatic brain injury (mTBI) and contributes to persistent visual symptoms. Comprehensive binocular vision and ocular motor assessments remain the diagnostic standard but may not be readily available. This study examined the a...

Proteogenomic profiling defines progression-associated biology in high-risk endometrial cancer

Patients with high-risk endometrial carcinoma (HR-EC) experience substantial mortality despite multimodality therapy, molecular classification and contemporary care. We determined whether proteomic tumor programs capture lethal risk beyond established clinical and genomic classif...

Does the National Resident Matching Program Rank List Predict Accreditation College of Graduate Medical Education Trainee Performance Among Multispecialty Pain Medicine Fellows? A Multicenter Study

Abstract Background Training programs seek to match fellows who will perform well during training. The National Resident Matching Program (NRMP) allows programs to choose the most capable trainees, with higher ranked applicants expected to perform better. Pain medicine is one of...

Natural Killer Cell Phenotypic Changes and Activating Receptor Loss Posttrauma

BACKGROUND: Trauma induces significant physiological changes that can lead to substantial morbidity and mortality. Many of these changes alter immune homeostasis, which underlies seemingly disparate syndromes of systemic inflammation and global immune suppression, the causes of w...