Walloon Excellence in Lifesciences and Biotechnology

Glycome remodeling programs pathogenic γδ T17 cell responses in autoimmunity

Glycans play fundamental roles in T cell biology; however, the glycome landscape of γδ T cells remains to be unlocked. Despite the growing importance of γδ T cells in host defense, tissue homeostasis, and diseases, the glycosylation mechanisms guiding their activation, commitment...

Selective dependency of CALR-mutant myeloproliferative neoplasms on TYK2 signaling

Abstract Myeloproliferative neoplasms (MPN) are driven by the oncoproteins JAK2V617F, mutant calreticulin (CALR), and mutant thrombopoietin receptor (TPOR; MPL), all of which activate JAK/STAT signaling. While JAK2 signaling is engaged in all MPNs, TYK2 is dispensable for JAK2V61...

Amygdala shows heterogeneous atrophy and tauopathy patterns across the AD continuum

Abstract Background Amygdala shows early vulnerability in Alzheimer’s disease (AD), although its substructures have been less studied than hippocampal subfields. Neuropathological evidence suggests that tau pathology affects amygdala subnuclei differentially, yet in vivo characte...

Animal models of autism spectrum disorder: Bridging biology to behaviour

Abstract The prevalence of autism spectrum disorder (ASD) has risen over the decades, reflecting improved awareness and evolving diagnostic practice. ASD is characterized by clinical and biological heterogeneity, with diverse genetic and environmental risk factors converging on d...

Total Synthesis of Paliurine E by a Highly Convergent Block Approach

ABSTRACT Macrocycles occupy a privileged position in chemistry, biology and medicine, yet their broader exploitation is curtailed by the lack of general, efficient synthetic strategies. Current approaches to macrocycle construction rely largely on stepwise linear assembly, protec...

Multi-level aggregation analysis of microbiome composition and host gene expression reveals associations with systemic and local immunity

ABSTRACT The human gut microbiome plays a critical role in immune regulation, yet the molecular links between microbiome composition and host gene expression remain incompletely understood. We analyzed associations between host gene expression and microbiome composition in a coho...

Ontogenically distinct mouse alveolar macrophages modulate cigarette smoke-induced lung inflammation via Spp1

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death. While airway-recruited macrophages contribute to COPD pathogenesis, the role of embryonic alveolar macrophages (Em-AM) remains unclear. Using a cigarette smoke (CS)-induced COPD mouse model, we find...