Wake Forest University

Evaluation of an institutional leadership program’s impact on skills and confidence

The Career Development for Women Leaders (CDWL) program was developed to enhance leadership skills for mid- and senior-career faculty through monthly sessions addressing leadership topics. Participants completed pre-, post-, and two-year follow-up program surveys, using items fro...

Responses to operant conditioning in the corn snake, Pantherophis guttatus, using olfactory and visual stimuli

Abstract Operant conditioning experiments have shown that a broad variety of animal species reliably form associations between a reinforced cue and the consequences of choosing it. Once established, these associations can serve as a basis for assessing behavioral flexibility, the...

Long-Term Fatigue After Treatment for Breast Cancer

Importance Patients with breast cancer (BC) may have long-term fatigue after treatment, which is associated with reduced quality of life. Objective To identify cardiac, psychological, and cancer treatment factors associated with fatigue before and 24 months after BC treatment. De...

Probing the neurochemical mechanisms of rTMS for alcohol use disorder: Results from a randomized, sham-controlled, double-blind, crossover, proton MR Spectroscopy study

Abstract With growing knowledge of the neural circuitry involved in alcohol use disorder (AUD), interest in developing neural-circuit-based therapeutic tools, including transcranial magnetic stimulation (TMS), for people with AUD has increased. While mounting evidence supports th...

Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study

Background: Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the completed LAANTERN prospective multicenter registry (NCT02392078), containing tumor patients enrolled in the study across 25 US cen...

Individual behavior and physiology of group housed mice in a spaceflight habitat

NASA has a robust history of biomedical investigations using rodent models in spaceflight. The results from these experiments have provided significant insights into the effects of spaceflight on mammalian physiological systems for fundamental, biomedical and commercial research...

Patient-centered approaches in psoriasis management: lessons from the past and future directions

INTRODUCTION: Psoriasis is a chronic immune-mediated disease with physical and psychosocial burden that is not fully captured by measures of skin lesion characteristics. Advances in therapies, including multiple biologic treatments, have improved disease control, but gaps remain...

Biomolecular Pathways Linking Preoperative Chronic Stress to Postoperative Cardiovascular Dysfunction in Noncardiac Surgery

Postoperative cardiovascular complications remain a leading cause of morbidity and mortality after noncardiac surgery, yet current risk models do not incorporate psychosocial stress. With over 300 million noncardiac surgeries performed annually worldwide and a substantial burden...

Expected reward value and reward prediction errors reinforce but also interfere with human time perception

Abstract Time perception is often investigated in animal models and in humans using instrumental paradigms where reinforcement learning (RL) and associated dopaminergic processes have modulatory effects. For example, interval timing, which includes the judgment of relatively shor...

Multidimensional Experimental Characterization of Lumbar Spinal Deformity

PURPOSE: Spinal deformities and motions of the spinal joints are rarely confined to a single anatomical plane. Yet diagnosis of such deformities and characterizations of their biomechanical behavior under load are often limited to two-dimensional methods of analysis. This study p...

Pre-registration: when does dynamics-aware tokenization pay off? (SFVT / TSB-AD-U)

Pre-registration of the predictions, frozen cutoffs, and analysis plan for testing whether the k-means token transition rate predicts when successor-field tokenization (SFVT) outperforms position-based tokenization on TSB-AD-U anomaly detection. Written before any anomaly-detecti...

Pre-registration: when does dynamics-aware tokenization pay off? (SFVT / TSB-AD-U)

Pre-registration of the predictions, frozen cutoffs, and analysis plan for testing whether the k-means token transition rate predicts when successor-field tokenization (SFVT) outperforms position-based tokenization on TSB-AD-U anomaly detection. Written before any anomaly-detecti...

Chronic ethanol vapor exposure suppresses ethanol self-administration and behavioral allocation in a concurrent operant choice paradigm in male and female Long Evans rats

RATIONALE: Access to alternative non-drug rewards is known to influence alcohol use, yet how chronic exposure affects behavioral allocation under concurrent choice conditions remains poorly understood. OBJECTIVES: This study examined the effects of chronic, binge-like ethanol vap...

Parental Concerns About Tap Water Associated With 4- to 6-Year-Old Children’s Increased Consumption of Sugar-Sweetened Beverages

Safe water is essential for children to comply with healthy beverage consumption recommendations. Tap water generates varying degrees of concern, including safety, health, taste, and so on. Perceptions of water quality may influence other beverages consumed, such as sugar-sweeten...

Region-Specific Brain Imaging Correlates of Repetitive Head Impact Exposure in Nonconcussed High School Football Players

Repetitive, nonconcussive head impacts in collision sports are associated with lasting neurophysiological effects. This study investigates region-specific changes in neocortical mean diffusivity (MD) and resting-state functional magnetic resonance imaging (fMRI) power spectral de...

Psychologizing, Authority, and Propaganda

Abstract When should we dismiss the reasons agents give for their views and instead invoke alternative psychological or causal explanations for their behavior? Philosophers such as Amy Flowerree and Nicholas Smyth have recently argued that we should generally avoid such dismissiv...

Autonomous Oxygen Titration for Maintaining Normoxemia in Acutely Ill Adults

Importance For acutely ill adults who are hospitalized with hypoxemia, supplemental oxygen is titrated to maintain normoxemia. In current practice, clinicians intermittently titrate oxygen, potentially exposing patients to hypoxemia and hyperoxemia between assessments. Autonomous...