Wakayama Medical University

Anti-inflammatory Effect of Electroconvulsive Therapy and Association Between Brain-Derived Neurotrophic Factor Increases and Nonrelapse

BACKGROUND: Electroconvulsive therapy (ECT) is effective for severe psychiatric disorders, but relapse after a successful acute course of ECT remains common. Identification of biological predictors of relapse is therefore clinically important. In this exploratory prospective stud...

Changes in hepatic functional reserve and renal function during hospitalization in patients with chronic liver disease

Evidence regarding inpatient rehabilitation for clinically complex patients with chronic liver disease (CLD), including those with advanced cirrhosis, remains limited. We aimed to describe real-world inpatient rehabilitation practice and unadjusted in-hospital changes in hepatic...

Role of calcineurin B homologous protein 3 in C2C12 myogenic differentiation

Calcineurin B homologous protein 3 (CHP3), also known as tescalcin, has been implicated in the regulation of cardiomyocyte hypertrophy, but its function in skeletal muscle remains unclear. Here, we investigated the role of CHP3 in C2C12 myogenic differentiation. CHP3 expression w...

Drug-Dependent Disruption of Amyloid Nanofibril-Mediated Wrinkling in Supraparticle Assemblies

Supraparticles (SPs) are secondary particles formed through nanoparticle self-assembly with porous architectures and bioinspired structural features suitable for drug delivery applications. Although binder-mediated structural control influences SP assembly, how different loaded d...

The structural dynamics and molecular coupling in the slow inactivation of a prokaryotic voltage-gated sodium channel

Slow inactivation in voltage-gated sodium channels (Navs) is crucial for regulating cell excitability. Many studies indicate that the selectivity filter (SF) serves as the inactivation gate, but the structural mechanism and coupling between the distal primary and inactivation gat...

Perioperative Durvalumab for Resectable NSCLC : Updated Outcomes for Japanese Patients in AEGEAN

ABSTRACT In the phase 3 AEGEAN study, perioperative durvalumab plus neoadjuvant chemotherapy significantly improved the primary endpoints of event‐free survival (EFS) and pathological complete response (pCR) in patients with resectable NSCLC versus neoadjuvant chemotherapy alone....

Tarlatamab in small cell lung cancer following platinum-based chemotherapy: subgroup analysis of Japanese patients from the DeLLphi-304 study

Abstract Background In the Phase 3 DeLLphi-304 trial, tarlatamab significantly improved overall survival (OS) over chemotherapy for small-cell lung cancer (SCLC) progressed after platinum-based chemotherapy. We report efficacy and safety in the Japanese subpopulation. Methods Pat...

A multicenter phase II trial of ramucirumab plus irinotecan for early recurrence of gastric cancer during or after adjuvant chemotherapy with docetaxel plus S-1 therapy: the RAMIEL trial (OGSG1901)

Abstract Background There is currently no established chemotherapy regimen for early recurrence of pathological stage III gastric cancer (GC) following adjuvant chemotherapy with docetaxel plus S-1 (DS) after D2 gastrectomy. We aimed to evaluate the efficacy and safety of ramucir...

Flow-driven lumen remodeling and valve opening in the vas deferens

ABSTRACT Biological ducts must transport fluids while preserving structural integrity, yet how mechano-signaling coordinates wall deformation with luminal flow in vivo remains unclear. Here we combine intravital two-photon excitation microscopy, light-sheet imaging and FRET-based...

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination disseminated in space and time. Here we performed a genome-wide association study (GWAS) using 688 MS cases and 205,199 controls from the Japanese population and...

Integrating Meta‐Analysis Into a Specific Study (InMASS) for Estimating the Target‐Population Average Treatment Effect

Randomized controlled trials remain the benchmark for estimating treatment effects, yet practical constraints often restrict sample sizes in a prespecified target population. In such settings, evidence from completed trials is frequently available only in aggregate form, which pr...

From educational seminars to interpersonal diffusion: knowledge fidelity in word-of-mouth transmission of HPV vaccine information in Japan—a real-world implementation study

Abstract Background In vaccine-hesitant environments, evidence-based health information often spreads through interpersonal word-of-mouth communication within community networks. However, little empirical evidence exists regarding whether health knowledge remains accurate as it i...

Pneumonitis in Older Patients With Non-squamous Non-small Cell Lung Cancer Treated With Pembrolizumab and Pemetrexed

Background/Aim: Pembrolizumab combined with pemetrexed is efficacious in older patients with metastatic non-squamous non-small cell lung cancer (NSCLC) and a PD-L1 tumor proportion score (TPS) of <50%. However, treatment-related pneumonitis is concerning, and its impact on clinic...

The Clinicopathological Characteristics and Prognosis of Cholangiolocarcinoma: A Multicenter Study With a Central Pathology Review

BACKGROUND: Cholangiolocarcinoma (CLC) is a rare liver cancer with ≥ 80% ductular configuration (DC). Given its rarity, its clinicopathological characteristics remain poorly understood, and its status as a distinct disease entity remains controversial. We conducted a nationwide m...