Viva Biotech (China)

Mitochondrial Dyes with Balanced Permeability-Fixability for Live, Fixed, and Expanded Multicellular Imaging

Abstract Mitochondrial inner-membrane ultrastructure plays a central role in cellular metabolism, aging, and cell death. However, super-resolution imaging of mitochondria after fixation remains challenging: commercially available fixable probes often lack sufficient reactivity fo...

Extracellular vesicle proteins monitor and interfere with CLDN18.2-targeted CAR-T cell and antibody therapies against gastrointestinal cancers

Abstract Claudin 18.2 (CLDN18.2)-targeted CAR-T cell and antibody therapies show promise against gastrointestinal cancers, but biomarkers predictive of long-term benefit and therapeutic sensitization strategies are needed. Here we show that proteins carried by circulating extrace...

Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking

Abstract Objective Type III collagen plays a key role in maintaining skin elasticity and dermal resilience, yet its decline is associated with visible signs of skin ageing. This study aimed to establish a data‐driven approach to identify cosmetic peptides with potential to enhanc...

Engineered hypoimmunogenic iPSC-derived mesenchymal stromal cells secreting high levels of functional FVIII ameliorate the hemophilia A phenotype

Background: Cell-based gene therapy represents a promising therapeutic avenue for genetic diseases such as hemophilia A (HA). However, clinical translation is limited by low transgene expression and host immune responses. Methods: Using CRISPR/Cas9, we targeted a codon-optimized...

Safety and antiviral activity of inhaled siRNA SNS812 for treatment of mild-to-moderate COVID-19: a phase 2 randomized trial

Abstract Background SARS-CoV-2 remains a global health threat because ongoing viral evolution and immune evasion reduce the effectiveness of existing therapies. SNS812 is an inhaled small interfering RNA targeting a highly conserved region of the viral RNA-dependent RNA polymeras...