Vinmec International Hospital

Post-TAVR Neo-Sinus Geometry and Impaired Ventricular Recovery Are Associated with Early Leaflet Thrombosis: First MDCT Insights from Vietnam

Background/Objectives: Leaflet thrombosis after transcatheter aortic valve replacement (TAVR), typically identified as hypoattenuated leaflet thickening (HALT) on multidetector computed tomography (MDCT), is increasingly recognized as an early manifestation of bioprosthetic valve...

Long-term outcomes of dual locking-plate fixation for bicondylar tibial plateau fractures via two mini-incisions: A prospective study

Background Bicondylar tibial plateau fractures are complex injuries that frequently involve a posteromedial fragment and carry a high risk of post-traumatic osteoarthritis. However, long-term outcome data on dual locking-plate fixation are limited, particularly in Southeast Asian...

Rational Designof Pyrrole-Based Ionizable Lipidsfor mRNA Delivery

Abstract Ionizable lipids are key components of lipid nanoparticles for mRNA delivery. Inspired by the DLin-KC2-DMA ionizable lipid, we developed a series of pyrrole-based ionizable lipids to evaluate the feasibility of incorporating a rigid heterocyclic scaffold into ionizable l...