Vinmec Times City International Hospital

Multistage Reconstruction of Complex Postburn Facial Scars: A Multidimensional Reconstructive Approach

Background: Severe postburn facial scars may involve multiple anatomical units with different functional and aesthetic requirements. Reconstruction of such deformities may therefore require a staged and individualized approach rather than a single reconstructive procedure. Case P...

Lymphocyte-to-monocyte ratio predicts survival in localized osteosarcoma in Vietnamese patients

Inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), alongside hemoglobin (Hgb) levels, have been proposed as prognostic tools in osteosarcoma, though their reliability remains unclear....

Post-TAVR Neo-Sinus Geometry and Impaired Ventricular Recovery Are Associated with Early Leaflet Thrombosis: First MDCT Insights from Vietnam

Background/Objectives: Leaflet thrombosis after transcatheter aortic valve replacement (TAVR), typically identified as hypoattenuated leaflet thickening (HALT) on multidetector computed tomography (MDCT), is increasingly recognized as an early manifestation of bioprosthetic valve...

Long-term outcomes of dual locking-plate fixation for bicondylar tibial plateau fractures via two mini-incisions: A prospective study

Background Bicondylar tibial plateau fractures are complex injuries that frequently involve a posteromedial fragment and carry a high risk of post-traumatic osteoarthritis. However, long-term outcome data on dual locking-plate fixation are limited, particularly in Southeast Asian...

Rational Designof Pyrrole-Based Ionizable Lipidsfor mRNA Delivery

Abstract Ionizable lipids are key components of lipid nanoparticles for mRNA delivery. Inspired by the DLin-KC2-DMA ionizable lipid, we developed a series of pyrrole-based ionizable lipids to evaluate the feasibility of incorporating a rigid heterocyclic scaffold into ionizable l...