Vietnam National Children's Hospital

Fulminant multisystem adenovirus-associated illness with cerebrospinal fluid PCR positivity and minimal pleocytosis in previously healthy toddlers: a case series

Central nervous system manifestations of human adenovirus infection are uncommon in immunocompetent children and may be difficult to recognize when routine cerebrospinal fluid (CSF) indices are normal or only minimally abnormal. We report a severe pediatric case series characteri...

Lessons from arthritis and osteomyelitis mimicking juvenile idiopathic arthritis: painlessness as an important clue to NTRK1 mutations

Congenital insensitivity to pain with anhidrosis (CIPA) is an extremely rare disorder that is caused by autosomal recessive mutations in the Neurotrophic Receptor Tyrosine Kinase (NTRK1) gene. The disease typically presents with a triad of insensitivity to pain and temperature, a...

Serum Endoglin as a Predictive Biomarker for Active Digital Ulcers in Systemic Sclerosis: A Case-Control Study

Introduction This study aimed to evaluate soluble endoglin (sENG) in serum as a potential biomarker of active digital ulcers (DUs) in systemic sclerosis (SSc). Methods This single-center, cross-sectional case-control study included 60 SSc patients, comprising 30 with active DUs a...

Facial Phenotypic Pattern in Severe Congenital Neutropenia Type 4 (G6PC3 Deficiency): Description and Clinical Value

Severe congenital neutropenia type 4 (SCN4) is an autosomal recessive disorder caused by mutations in the third subunit of the enzyme glucose-6-phosphatase (G6PC3). Patients with mutations in G6PC3 suffer from congenital neutropenia and additional complex developmental abnormalit...

Pre-stroke frailty and 30-day functional outcomes in Vietnamese adults with acute stroke: a prospective observational study

Abstract Background Pre-stroke frailty may influence recovery after acute stroke, but prospective evidence from low- and middle-income countries remains limited. We investigated the association between pre-stroke frailty and 30-day functional outcome among Vietnamese adults with...

Evidence Synthesis of Probiotic Supplementation for Allergic Rhinitis in Adults: A Systematic Review and Network Meta-Analysis

Background Probiotics are increasingly explored as a potential adjunctive treatment for allergic rhinitis, a condition affecting approximately one in five adults worldwide. Despite distinctive age-related differences in gut microbiota composition, immunologic characteristics, and...

Primary gastric melanoma in an Asian patient: a rare case report of early detection and therapeutic uncertainty

Introduction and importance: Primary gastric melanoma (PGM) is an exceedingly rare malignancy, especially in Asian populations, that presents major diagnostic and therapeutic dilemmas. Presentation of the case: We report the case of a 53-year-old Vietnamese man who presented with...

How to Train Your Chatbot: Information‐Theoretic Foundations of Diagnostic Questioning in Inborn Errors of Immunity

BACKGROUND: Navigating the more than 550 inborn errors of immunity (IEI) requires efficient diagnostic reasoning. Information theory suggests questions should be prioritized by their capacity to reduce diagnostic uncertainty (entropy); yet whether experts or large language models...

Percentiles for crying, regurgitation, stool consistency, and CoMiSSTM in presumed healthy infants

Parents frequently consult health care professionals because of infant regurgitation, crying and stool consistency. The Cow’s Milk-related Symptom Score (CoMiSS TM ) is an awareness tool for cow’s milk allergy. We aimed to characterize the distribution of CoMiSS items in presumed...

Caregiver perspectives on inpatient service quality at a pediatric hospital in Vietnam: a mixed-method study

Assessing the quality of inpatient services is essential for improving healthcare performance and ensuring patient-centered care, particularly in pediatric hospital settings. Although Vietnam has implemented national hospital quality assurance frameworks, empirical evidence on pe...

Neonatal antibody levels and treatment outcomes following maternal vaccination among NICU infants exposed to COVID-19 during pregnancy

The COVID-19 pandemic has profoundly affected maternal and child health worldwide, with pregnant women being particularly vulnerable to complications. Vaccination during pregnancy has been shown to generate protective antibodies offering passive immunity to neonates, though conce...

Association Between Upper Airway Morphology and Pulmonary Function in Vietnamese Orthodontic Patients: A Cone-Beam Computed Tomography and Computational Fluid Dynamics Study

Background: Current evidence on the relationship between upper airway morphology and respiratory function remains inconsistent and inconclusive. Although anatomical narrowing is often linked to respiratory impairment, its effect on measurable pulmonary function in asymptomatic in...