Victorian Infectious Diseases Reference Laboratory

Reconciliation of titer differences between SARS-CoV-2 neutralizing antibody assays

ABSTRACT SARS-CoV-2 antibody neutralization is a correlate of protection for COVID-19 and has been used to guide public health decisions. However, there is no standard neutralization assay, and absolute titers differ between assays. To investigate mechanisms causing these absolut...

Metabolic reprogramming enables transient survival and envelope remodelling in Staphylococcus aureus under dalbavancin treatment

Clinical failure of antibiotic therapy can occur in the absence of measurable resistance, yet the biological basis of this discordance remains poorly understood. Here, we identify a transient survival phenotype that limits dalbavancin efficacy and may contribute to treatment fail...