VIB-KU Leuven Center for Microbiology

High-throughput protocol for assessing antibiotic resistance using agar dilution, acoustic liquid handling, and semi-automated image analysis

Conventional minimum inhibitory concentration (MIC) assays used to determine the antibiotic susceptibility of microorganisms are inherently low-throughput and labor intensive. Here, we present a high-throughput agar dilution MIC assay to efficiently assess resistance profiles acr...

Warped Geometries of Segre–Veronese Manifolds

Abstract. Segre–Veronese manifolds are smooth submanifolds of tensors comprising the partially symmetric rank-1 tensors. We investigate a one-parameter family of warped geometries of Segre–Veronese manifolds which includes the standard Euclidean geometry. This parameter controls...

The sweet spot in protein design—Where deep learning meets first principles

This Perspective explores recent methods and prospective ideas for developing hybrid AI-physics-based pipelines for protein and antibody de novo design. We argue that the highest-confidence candidates emerge where deep learning and first-principles models agree, a "sweet spot" th...