Vertex Pharmaceuticals (United States)

Bayesian variable selection on small sample trial data via adaptive posterior-informed shrinkage prior

Identifying variables associated with clinical endpoints is a central objective in clinical trials. With the rapid expansion of cell and gene therapies (CGTs) and therapeutics for ultra-rare diseases, there is an urgent demand for statistical methods capable of detecting meaningf...

Telescoped Two-Step Deaminative Ni-Catalyzed C(sp 2 )–C(sp 3 ) Cross-Electrophile Coupling for Late-Stage Parallel Library Synthesis

Abstract A two-step deaminative C(sp2)–C(sp3) cross-electrophile coupling (XEC) protocol to enable late-stage parallel library diversification of medicinally relevant aryl halides is reported. In the first step, sodium pivalate facilitates the condensation of primary amines with...

Early life exposures association with later diagnosis of spondyloarthritis: A population-based case-control study

Objective To assess whether early-life antibiotics are associated with spondyloarthritis (SpA) diagnosed by age 21. Methods In this population-based, matched case–control study, we used Danish live births (1997-2023) restricted to those reaching minimum relevant ages by December...

Suzetrigine as Part of Multimodal Therapy Enables Opioid-Free Recovery after Laparoscopic or Arthroscopic Procedures

Suzetrigine, a non-opioid voltage-gated sodium channel 1.8 (Na V 1.8) pain signal inhibitor with no addiction potential, is approved in the USA for moderate-to-severe acute pain. In this phase 4, single-arm study, suzetrigine (100 mg preoperatively, then 50 mg every 12 h) was adm...