Vavilov Institute of General Genetics

Comparative genomic analysis of the CsoR-family Ni2+/Co2+ regulators

Metals are essential for many cellular processes, yet at excessive levels they are toxic, therefore metal concentrations in a cell must be tightly regulated. In bacteria, such regulation is often carried out by transcription factors (TFs). Here, we use comparative genomics approa...

An Extremely Rare ZP4 Missense Variant in a Patient with Abnormal Zona Pellucida Morphology and Female Infertility: A Case Report

Background and Clinical Significance: The oocyte zona pellucida (ZP) is an extracellular glycoprotein matrix with essential roles in oogenesis, fertilization, and early embryonic development. Abnormal ZP morphology is associated with female infertility and adverse outcomes after...