Institution
Vanderbilt-Ingram Cancer Center
Recent research
- Health & MedicineOpen access
Response assessment criteria in patients with higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) have been updated in the 2023 International Working Group (IWG) criteria. However, validation of these criteria has been limited to date. We analyzed overall survival (OS) by be...
- BiologyOpen access
Epigenetic insights into extreme longevity in the world’s oldest terrestrial animal, Jonathan
Aldabra giant tortoises ( Aldabrachelys gigantea ) are exceptionally long-lived. We sequenced the genome and methylome of Jonathan, a 194-year-old Aldabra, to explore the molecular basis of his longevity. Relative to other giant tortoises ( A. gigantea and Chelonoidis abingdonii...
- BiologyOpen access
Abstract Plasma cell-free DNA (cfDNA) is a sensitive, noninvasive tool for monitoring the genomic landscape, heterogeneity, and evolution of cancer, aggregating genetic information from multiple metastatic sites. Here, we study 15,564 cfDNA samples from 12,827 patients with metas...
- Health & MedicineOpen access
The CAUSAL study: a prospective cohort of sarcoma survivors across the lifespan
Sarcomas affect individuals across the lifespan, yet no cohort study exists evaluating contributors to treatment response, survival and health outcomes among contemporarily treated sarcoma patients. Determining disease, treatment, lifestyle, and genomic factors that contribute to...
- Health & MedicineOpen access
The American Board of Internal Medicine Research Pathway (ABIM RP) is designed to train physician-scientists by shortening postgraduate clinical training and increasing research time. We surveyed ABIM RP graduates to understand career trajectories, research engagement, and barrie...
- BiologyOpen access
Prioritizing clinical utility to use allostatic load as a biomarker of the consequences of stress
Allostatic load measures the physiological consequences of stress and is associated with disease outcomes. Clinical use of allostatic load is limited, in part, because its calculation requires biomarkers not routinely measured in clinical care. Presently, we evaluated association...