Vancouver General Hospital

Distal Radial Access for Thoracic Branch Endoprosthesis Deployment: Two Cases of Successful TEVAR with Left Subclavian Artery Revascularization

Background and Clinical Significance: Thoracic endovascular aortic repair (TEVAR) involving zone 2 of the aortic arch frequently necessitates left subclavian artery (LSA) revascularization to reduce the risk of neurologic and ischemic complications. If endovascular methods are em...

Diagnosis and management of transthyretin amyloidosis (ATTRv) across ATTRv-PN and mixed phenotype: an international delphi consensus

Abstract Background Transthyretin amyloidosis is a progressive, potentially fatal genetic disorder primarily associated with polyneuropathy (ATTRv-PN) or cardiomyopathy (ATTR-CM). Disease presentation is heterogenous. Patients often present with a mixed phenotype. Although recent...

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

Cefepime and Mortality

Importance Cefepime is recommended for the treatment of febrile neutropenia and gram-negative infections at moderate risk of ampicillin resistance locus C β-lactamase production. Concerns regarding cefepime’s safety have been raised in the literature without firm conclusions. Obj...

Spontaneous gallbladder perforation: An under-recognized complication in patients with decompensated liver cirrhosis

Abstract Background: Gallbladder perforation is a rare but life-threatening condition with high mortality. Patients with decompensated liver cirrhosis may be at increased risk; however, spontaneous or occult gallbladder perforation in this population is poorly recognized. This ca...

Timing and Incidence of Airway Interventions Following Occipitocervical Fusion: A Retrospective Study Using the Nationwide Inpatient Sample 2017 to 2022

Background: Occipitocervical fusions (OCFs) are associated with adverse airway events. The period of airway compromise remains poorly defined. The objective of this study was to identify differences between OCF and posterior cervical fusion not involving the occipitocervical join...

Validation of the AO Spine Osteoporotic Fracture Classification—effect of geographical region on reliability and reproducibility

Regional differences affect the reliability of the AO Spine-DGOU Osteoporotic Fracture Classification. European participants showed the highest agreement. This study underscores the need for addressing regional factors to improve the system’s global clinical utility. To evaluate...

Application of a dynamic wound closure device in orthopaedic trauma patients following fasciotomy: A level-1 trauma center perspective and preliminary case series

Abstract The challenge of achieving delayed primary closure of fasciotomy wounds is well known, and multiple techniques of achieving either delayed primary closure or alternative forms of soft-tissue reconstruction have been described in the literature. However, a universally acc...