Vancouver Coastal Health

Interaction of physical fitness and resting state functional connectivity on global cognitive function in older adults with mild cognitive impairment

Background Mild cognitive impairment (MCI) represents a prodromal stage of Alzheimer's disease. Physical fitness, including cardiorespiratory fitness and muscular strength, is associated with cognitive function in older adults. Resting-state functional connectivity (rsFC) is also...

A review of policy actions implemented during a toxic drug public health emergency in British Columbia, Canada (2016–2024)

Background During a decade-long public health emergency, driven by a highly unpredictable unregulated drug supply, drug toxicity remains the leading cause of unnatural death in British Columbia (BC), Canada. In response, the province implemented a multi-faceted approach to preven...

Practical Insights from Operationalizing a Remote Symptom Monitoring Program Using a Commercial Platform in a Canadian Community Cancer Clinic: A Post-Implementation Qualitative Evaluation

Remote symptom monitoring using electronic patient-reported outcomes reduces symptom burden and acute care use in oncology, but most programs have been established in academic centers or funded trials using purpose-built software. We examined how the REmote Symptom and Patient mO...

Granzymes in Neuroinflammation and Neurodegenerative Diseases

Abstract Neuroinflammation is a central driver of numerous neurological disorders. While granzymes have classically been studied as cytotoxic effector molecules secreted from immune cells along with the pore-forming molecule, perforin, accumulating evidence suggests that these se...

Resilience and Protective Factors for Mental Health among Indigenous Youth in Canada: A Scoping Review

Abstract Indigenous youth’s inherent strength and resilience play a vital role in their well-being and mental health. Protective factors, closely linked to resilience, spanning individual, family, and community levels reinforce positive mental health outcomes. The purpose of the...

Terminology for describing the 24-h cycle of physical activity, sedentary behaviour, and sleep: a scoping review

Abstract Background Physical activity, sedentary behaviour, and sleep are three behaviours which occupy the 24-h cycle and interact to influence a multitude of health outcomes. Different terms are currently used to describe these behaviours collectively (e.g., movement behaviours...