Van Yüzüncü Yıl Üniversitesi

Evaluation of Systemic Protein Carbonylation and Glutathione-Dependent Enzymatic Antioxidant Defense Line in Diabetic Foot Syndrome

Objective: Diabetic foot syndrome is a debilitating complication of diabetes mellitus closely tied to chronic metabolic dysregulation. This study aimed to evaluate circulating oxidative protein damage and the status of the glutathione-dependent enzymatic antioxidant defense syste...

Acoustic Radiation Force Impulse Elastography for Differentiating Adenomyosis and Uterine Leiomyoma: A Prospective Histopathology-Validated Study with Moderate Diagnostic Performance

Purpose To evaluate the diagnostic performance of Acoustic Radiation Force Impulse (ARFI) elastography in differentiating adenomyosis from uterine leiomyoma and to compare its diagnostic accuracy with magnetic resonance imaging (MRI). Methods This prospective study included 164 p...

Effects of a Benzimidazolium Salt on Colorectal Cancer Cells: Involvement of Apoptosis and Autophagy

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, necessitating the identification of novel small molecules capable of targeting multiple survival pathways. In this study, the antiproliferative potential of dds benzimidazole-palladium (Pd) com...

Microbial Biostimulants for Drought Resilience in Plants: Mechanisms, Plant–Microbiome Interactions, and Sustainable Agricultural Applications

Drought stress is one of the most significant challenges for global agriculture, adversely affecting crop yields and food security. In recent years, microbial biostimulants have emerged as a promising solution to enhance plant resilience against such abiotic stresses. This review...

The Effect of Patellar Height on Load Distribution in the Knee: Is It a Risk Factor for Meniscal Tears?

Objective: The aim of this study was to determine the frequency of patella alta in patients with arthroscopically confirmed meniscal tears and to evaluate the relationship between patellar height and the side, anatomical location, and type of meniscal tears. Materials and Methods...

The Effect of Leading Macroeconomic Indicators on Energy Consumption: The Case of Turkey

Energy consumption is of significant macroeconomic importance. Studies have shown that energy consumption influences macroeconomic indicators, and conversely, macroeconomic indicators affect energy consumption. This study deviates from the general trend in the literature by exami...

Real-world outcomes of children with first relapsed acute lymphoblastic leukemia treated according to the ALL-IC REL 2016 guideline in Türkiye

Relapsed acute lymphoblastic leukemia (ALL) remains a major challenge in pediatric oncology, particularly where access to modern immunotherapies is limited. This national multicenter study evaluated real-world outcomes of children with first relapsed ALL treated according to the...

Patent-augmented knowledge graph drug repurposing for duchenne muscular dystrophy: a time-sliced evaluation

Patent documents may complement curated biomedical resources, but adding patent-derived relations to a knowledge graph does not itself establish improved drug-repurposing prediction or mechanism. We evaluated patent augmentation in a historical, time-sliced Duchenne muscular dyst...

Quantitative Pharmacokinetic Analysis of Dynamic Contrast-Enhanced Perfusion in Multiparametric Prostate MRI: An Exploratory Intra-Patient Study Differentiating Malignant Lesions from Normal Tissue

Background/Objectives: To quantitatively evaluate pharmacokinetic parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in differentiating prostate malignant lesions from normal appearing prostatic tissue, and to analyze their correlation with Gle...

Evaluation and Optimization of COD Removal Performance for a Domestic Wastewater Treatment Plant by Response Surface Methodology: The Case of Van Muradiye

ABSTRACT In this study, the performance of the Van Muradiye Domestic Wastewater Treatment Plant was evaluated with Response Surface Methodology (RSM). The effects of pH, conductivity, dissolved oxygen (DO), and suspended solids (SS) on the chemical oxygen demand (COD) removal eff...

HCQ-SGuA: A Plant-Growth-Inspired Hybrid Saplings Growing Up Algorithm with Quasi-Random Initialization and Chaotic Operator Control for Continuous Optimization

Metaheuristic optimizers often suffer from premature convergence, diversity loss, and stagnation in complex search landscapes. This study proposes HCQ-SGuA, a plant-growth-inspired framework that strengthens the Sowing phase through structured population initialization and regula...

Fırçalı DA Motorlarda Açık Veri Seti İle Makine Öğrenmesi Tabanlı Kestirimci Bakım ve Arıza Teşhisi

Fırçalı Doğru Akım (FDA) motorları, endüstriyel otomasyon sistemlerinde ve tahrik mekanizmalarında yaygın olarak kullanılmakta olup, fırça aşınması ve sargı deformasyonları beklenmedik duruşlara ve yüksek bakım maliyetlerine neden olabilmektedir. Bu çalışmada, fırçalı DA motorlar...

Ömer Demirbağ’ın Dîvân’ındaki Şiirlerine Aşk, Âşık ve Mâşuk Kavramları Ekseninde Bir Bakış

Bu çalışmada günümüz şâirlerinden Ömer Demirbağ’ın Dîvân’ındaki şiirleri aşk, âşık ve mâşuk kavramları ekseninde incelenmiştir. Onun aruz vezni ve gazel nazım türüyle yazmış olduğu bu şiirleri dîvân şiiri geleneğinin günümüzdeki devamı niteliğindedir. Her ne kadar dîvân şiiri gel...

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL PYRAZOLE-BARBITURATE HYBRIDS AS ALPHA-GLUCOSIDASE INHIBITORS

Objective: Type 2 diabetes is a global health problem marked by chronic hyperglycemia. α-Glucosidase inhibitors help regulate postprandial glucose levels, but current drugs have side effects and limited efficacy. This study aimed to develop novel pyrazole–barbiturate hybrids as m...

The Prognostic Value of the Advanced Lung Cancer Inflammation Index on Disease-Free Survival in Patients with Gastric Cancer Receiving Neoadjuvant Chemotherapy

Objectives: The present study investigated whether the pre-treatment Advanced Lung Cancer Inflammation Index (ALI) could serve as a prognostic indicator of disease-free survival (DFS) in patients with locally advanced gastric cancer treated with neoadjuvant chemotherapy followed...

Quinine modulates PD-L1 and STAT3 in MCF-7 cells: An in silico and in vitro study

Programmed death-ligand 1 (PD-L1) overexpression in cancer cells is linked to immune escape and tumor progression, with signal transducer and activator of transcription 3 (STAT3) as a key transcription factor regulating its expression. This study evaluates the potential of quinin...

Dose-dependent cholinergic, inflammatory, and genotoxic effects of etoxazole in female Wistar rats

Etoxazole is a widely used oxazoline acaricide in agriculture; however, its toxicological profile in mammalian systems remains insufficiently characterized. This study investigated the dose-dependent effects of subchronic etoxazole exposure on serum biochemical, genotoxic, and ha...

Investigation of the relationship between breastfeeding myths and breastfeeding adaptation: a correlational survey study

The early postpartum period is a critical time frame in which mothers’ adaptation to breastfeeding is shaped and breastfeeding-related beliefs become evident. The aim of this study was to examine the relationship between the level of belief in breastfeeding myths and breastfeedin...

Early hormonal responses of irisin and nesfatin-1 following sleeve gastrectomy in women with obesity: A preliminary study

Laparoscopic sleeve gastrectomy (LSG) is an effective surgical intervention for morbid obesity, yet early hormonal changes contributing to metabolic adaptation remain underexplored. The objective of this study was to evaluate the early postoperative changes in the energy-regulati...

The effects of educatıon on chıldhood vaccınes gıven to pregnant women on vaccıne hesıtancy and vaccıne lıteracy: a randomızed controlled experımental study

The study aims to evaluate the effects of face-to-face education initiative supported by the “Educational Guide on Childhood Vaccination Hesitancy” given to pregnant women by the researcher on vaccine hesitancy and vaccine literacy. The present study was conducted as a pre-test/p...