VA Portland Health Care System

Modeling the heterogeneity of cognitive dysfunction in Parkinson’s disease using partially ordered set models

Abstract Traditional binary classifications of Parkinson’s disease (PD) cognitive dysfunction fail to capture its inherent heterogeneity. This study introduces the Partially Ordered Set (POSET) model, a Bayesian framework, to analyze cognitive heterogeneity using Parkinson’s Prec...

The VA HEARS Model for Predicting Audiogram Changes in Adults Undergoing Cisplatin Chemoradiotherapy

Objective: Develop and validate a model for predicting complete audiograms of individual patients that also supports cisplatin-ototoxicity forecasting and early identification using any existing diagnostic and classification criteria. Study design: Prospective observational study...

Effects of time-restricted eating in early-stage Huntington’s disease: a pilot study

Time-restricted eating (TRE) has shown neuroprotective potential in preclinical models of Huntington’s disease (HD) but has not been tested clinically. Here, we report the results of a 12-week open-label pilot trial ( NCT06490367 ) of 8-h TRE, alongside standard-of-care diet and...

Long-Term Follow-Up to Study of Timing of Rehabilitation After Mild Traumatic Brain Injury

Jae W Lee, PhD, Kody R Campbell, PhD, Prokopios Antonellis, PhD, Jennifer L Wilhelm, PT, DPT, Kathleen T Scanlan, PT, DPT, Siting Chen, MPH, Robert J Peter

Characterizing Communication in Group Settings Following Traumatic Brain Injury: Development of the Multiparty Communication Questionnaire

Purpose: Group, or multiparty, settings present a particularly challenging communication context for speakers, who must keep track of a myriad of interpersonal, informational, and contextual factors and then flexibly adjust their language to meet the needs of the group. While the...

Sleep Management and Recovery After TBI in Kids (SMART-Kids): Pilot Trial Using Melatonin

OBJECTIVE: Sleep disturbances after pediatric traumatic brain injury (TBI) occur in more than 50% of survivors and portend worse cognitive and psychosocial outcomes. We aimed to determine feasibility and acceptability of an early melatonin and sleep education intervention study a...

Normative Ranges for Auditory Brainstem Response Wave I Amplitude: A Potential Diagnostic Indicator of Cochlear Deafferentation

PURPOSE: While cochlear synaptopathy has limited impact on auditory thresholds, there is increasing evidence that cochlear deafferentation is associated with auditory perceptual deficits. However, there is currently no means for diagnosing synaptopathy or deafferentation in indiv...

Examining the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) Moderate Risk Cannabis Use Threshold Among a Sample of U.S. Military Veterans with Chronic Pain Who Report Medical Cannabis Use

BACKGROUND: The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) is widely used for substance use screening. However, its established risk cutoffs may not be appropriate for people who use cannabis for medical reasons. This study sought to determine an optimal m...