VA New England Healthcare System

Posttraumatic Stress Disorder, Health-Related Social Needs, and Cognitive Outcomes in US Veterans

Importance Posttraumatic stress disorder (PTSD) and health-related social needs (HRSNs) have been associated with cognitive decline, but their joint associations with mild cognitive impairment (MCI), Alzheimer disease (AD), and AD-related dementias (ADRD) are unclear. Objective T...

Artificial Intelligence in Counseling and Counseling Psychology: A Counselor-Led Framework for Ethical Practice & Training

As generative artificial intelligence (AI) tools like ChatGPT become increasingly accessible, counseling psychologists are exploring their potential use in clinical practice, often without clear guidance or ethical frameworks. This paper presents a counselor-led model for integra...

Transcriptome signatures associated with cognitively unimpaired individuals with pathologically confirmed Alzheimer disease

There is growing interest in cognitive resilience to Alzheimer’s disease (AD), given limited success of therapies targeting hallmark proteins. Gene expression in the prefrontal cortex region obtained from brain donors in three cohorts was compared among pathological controls and...

Proteomic analysis of human chronic traumatic encephalopathy brain implicates proteasome and ribosome dysfunction in disease severity

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that occurs in individuals with repeated head impacts (RHI) exposure, including contact sport athletes, military personnel, and domestic abuse victims. Despite growing recognition of CTE, the molecular mechanis...