VA Greater Los Angeles Healthcare System

Sucralose Alters Gut Microbiota, Intestinal Metabolites, and Epithelial Serotonergic Responses to Visceral Stimulation in Mice Exposed to Chronic Restraint Stress

Background/Objectives: Dietary modifiers of the gut ecosystem may influence intestinal and host responses associated with psychological stress. However, it remains unclear whether sucralose, a widely consumed non-nutritive sweetener, alters host–microbiota interactions following...

Lipids in endothelial-to-mesenchymal transition

Purpose of review Endothelial-to-mesenchymal transition (EndMT) has been implicated in the development of cardiovascular disease, including atherosclerosis. EndMT is a complex continuum with multiple involved pathways, each with different pathophysiologic implications depending o...

Chronic oral exposure to didecyldimethylammonium chloride induces region-specific intestinal dysfunction and gut microbiota remodeling in mice

bstract Didecyldimethylammonium chloride (DDAC) is a widely used quaternary ammonium disinfectant, but its effects on intestinal physiology following chronic oral exposure remain poorly understood. Here, we investigated the impact of chronic dietary DDAC exposure on intestinal fu...