VA Ann Arbor Healthcare System

Caregiver Symptom Misrepresentation to Obtain Antibiotics in Pediatric Encounters

This survey study examines the prevalence, reasons for, and characteristics associated with caregivers’ self-reported misrepresentation of symptoms to obtain antibiotics for their child.

Psychoplastogens to Reduce Persistent Cognitive Symptoms for Traumatic Brain Injury as a Chronic Condition

There are currently no available effective pharmacological therapies for treating chronic cognitive deficits after traumatic brain injury (TBI). Psychoplastogens, including atypical psychedelics, classical serotonergic psychedelics, and neuroplastogens, are a class of small molec...

Catheter-Associated Urinary Tract Infection Prevention Practices in US Hospitals

Importance Catheter-associated urinary tract infection (CAUTI) remains a common and morbid health care–associated infection. Although evidence-based prevention strategies are well established, the degree to which hospitals adopt and sustain these practices over time and whether t...

Improving Medication Classification in GLP‐1RA Research: Feasibility of a Photo‐Review Protocol

ABSTRACT Objective Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) are dominating the type 2 diabetes and obesity intervention landscape, yet their real‐world use is increasingly difficult to characterize amid widespread availability of non–FDA‐approved, compounded products...

Conserved C-terminal residues adjacent to the canonical PDX1 homeodomain are required for chromatin occupancy and pancreas development

Essential roles for the PDX1 transcription factor in pancreatic development and β-cell function are well-known, yet the structure-function relationships of domains within its C-terminus remain incompletely defined. We identified a focal intrinsically disordered region (IDR) spann...

Sharp cell type boundaries emerge from coordinated morphogen signaling

Classic models of the French flag problem depict sharp cell type boundaries emerging from threshold responses to morphogen gradients. How discrete cell type boundaries arise from morphogen signals that vary continuously across developing tissues remains incompletely understood. W...

Perceptions of Incidental Findings on Lung Cancer Screening Exams: A National Survey of Primary Care Clinicians and Radiologists

RATIONALE: Unlike other common cancer screenings, annual lung cancer screening often identifies a spectrum of incidental findings unrelated to lung cancer. While these findings could be actionable, how to best communicate and manage them can be a challenge, often falling upon pri...

Radiology considerations for the PREMIUM study: a multicenter randomized controlled trial of abbreviated MRI versus ultrasound for liver cancer screening in cirrhosis

Abstract This paper describes the rationale and radiology considerations in the implementation of the Preventing Liver Cancer Mortality through Imaging with Ultrasound versus MRI (PREMIUM) study. PREMIUM is a multicenter, randomized controlled trial sponsored by the Department of...

Assessing Emergency Clinicians' Needs From Trauma Clinical Guidance: A Mixed-Methods Study.

BACKGROUND: In the United States, emergency clinicians are often the first to care for injured patients in the hospital setting. Current trauma clinical guidance does not consistently meet the needs of emergency clinicians caring for this population. OBJECTIVES: To better underst...