USC Norris Comprehensive Cancer Center

Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma

Abstract DNA damage from routine cellular processes or exogenous insults can have a lasting impact on gene regulation beyond genetic mutations. The prevailing paradigm for the consequences of DNA damage repair revolves around restoration of the original genetic sequence, but long...

“Molecular divergence shapes lung- and liver-preferential metastasis in HER2-positive breast cancer”

Abstract Metastatic colonization of distant organs remains the primary cause of breast-cancer-specific mortality, yet the underlying mechanisms governing organ-preferential colonization remain poorly understood. To better delineate the underlying mechanisms to establish successfu...