Urmia University of Medical Sciences

Harnessing stem cell-based therapies for Alzheimer’s disease: mechanism, challenges, and future perspectives

Alzheimer’s disease (AD) affects more than 55 million people worldwide, and current pharmacological treatments provide only modest symptomatic benefits with limited effects on disease progression. Stem cell-based therapies, including mesenchymal stem cells (MSCs), neural stem cel...

Bifidobacterium longum prevent the progression of colon cancer via inhibiting metastasis and angiogenesis

Colorectal cancer (CRC) is one of the most common reasons for cancer-related death, and both angiogenesis and metastasis have established roles in CRC progression. Recent findings suggest that probiotics, like Bifidobacterium longum, are capable of suppressing anti-cancer activit...

Prevalence of hyperthyroidism in infertile women referred to assisted reproductive technology centers affiliated with Urmia University of Medical Sciences: a retrospective cross-sectional study

Abstract Background Thyroid dysfunction, particularly hyperthyroidism, is a recognized modulator of female fertility, yet its prevalence among infertile women remains inadequately characterized. This study aimed to determine the prevalence of biochemical hyperthyroidism among inf...

Salinomycin modulates viability, invasion, and inflammatory responses in primary endometriotic stromal cell cultures in association with Wnt/β-catenin signaling

Endometriosis is a chronic inflammatory disorder characterized by aberrant stromal-cell behavior, including enhanced invasion, resistance to apoptosis, and sustained cytokine production. Dysregulation of Wnt/β-catenin signaling has been linked to these pathological features, emph...

Rational design of short hybrid Cecropin B/Aurein 1.2 peptide analogues: in vitro synergistic anti-MRSA and anti-biofilm activities

Abstract Background The increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and the limited efficacy of conventional antibiotics necessitate the development of novel antimicrobial agents. This study aimed to design short hybrid antimicrobial peptides deriv...

Platelet–neutrophil cooperation in premetastatic niche formation: from NETosis and stromal conditioning to nanotherapeutic interception

Metastasis remains the leading cause of cancer-related mortality, yet the metastatic cascade is initiated long before circulating tumor cells reach distant organs. Central to this early phase is the premetastatic niche (PMN), a dynamic and tumor-conditioned microenvironment in wh...

The relationship between mental health, marital relationship quality, and attitude toward childbearing among married couples in Khoy, Northwest Iran: a cross-sectional study

Attitude toward childbearing is an important factor influencing reproductive decisions and may be affected by psychological and interpersonal factors. This study aimed to examine the relationship between mental health, marital relationship quality, and attitude toward childbearin...

From fear to bonding: a randomized controlled trial of CBT-based group counseling on the experience of becoming a mother in marginalized adolescent mothers

Adolescent motherhood, especially in marginalized populations, presents psychological and emotional challenges that can affect maternal-infant bonding and maternal self-efficacy. This study evaluated the effect of cognitive-behavioral group counseling on the experience of becomin...

Exploring contributing factors to fatalities occurring within an emergency department: a qualitative analysis informed by root cause analysis principles

Emergency Departments (EDs) are highrisk and timepressured workplaces where latent system failures can quickly culminate in fatal outcomes. Understanding the underlying causes contributing to mortality in these units is therefore essential for designing effective safety intervent...