Uppsala University Hospital

Autonomic function and signal complexity reflect level and severity of traumatic spinal cord injury

Abstract Study design Observational single-centre cohort study. Objectives To investigate heart rate variability (HRV), baroreflex sensitivity (BRS), and signal complexity (SC) and their relationships with neurological injury level and severity, as well as their prognostic value...

Combined effects of long‑term air pollution exposures on adult active asthma: a quantile g-computation analysis

Abstract Background Air pollution is a well‑established risk factor for the development of asthma, yet most studies examine pollutants individually, failing to capture the health effects of real‑world pollutant mixtures. Assessing long-term multipollutant exposure is essential fo...

A DPP6 ‐Targeted PET Tracer for Non‐Invasive Imaging of Transplanted Human Islets

ABSTRACT Introduction Dipeptidyl peptidase‐like protein 6 (DPP6) is a potential molecular imaging biomarker for pancreatic and transplanted islets of Langerhans. 4hD29 is a single‐domain antibody with nanomolar affinity for DPP6. Here, we demonstrate the generation and validation...

Speech-Language pathologists’ experiences introducing a modified Intensive comprehensive aphasia programme (mICAP) in regular healthcare: a multicentre mixed method study

Background There is limited knowledge of Speech-Language Pathologists’ (SLPs) experiences of delivering modified Intensive Comprehensive Aphasia Programmes (mICAPs) in regular healthcare. While such programmes show clinical promise, their feasibility in routine practice remains u...

Cardiovascular and thromboembolic risk in anti-neutrophil cytoplasmic antibody-associated vasculitis: a nationwide matched cohort study by disease, sex, and familial risk

OBJECTIVES: To investigate influence of sex, diagnosis (granulomatosis with polyangiitis (GPA) vs. microscopic polyangiitis (MPA)), and familial factors on cardiovascular disease and thromboembolism (CVD-TE) risk in patients with anti-neutrophil cytoplasmic antibody-associated va...

The plasma protein profile of left ventricular diastolic function

We aimed to characterize associations between plasma proteins and indices of left ventricular (LV) diastolic function in two population-based studies. Eighty-six cardiovascular-related plasma proteins measured by proximity extension assay (PEA) and echocardiography were assessed...

Inhibitory neurotransmission in frontostriatal circuitry: implications for psychomotor and vegetative symptoms in depressive episodes

Abstract Background Gamma-aminobutyric acid (GABA) dysfunction has been implicated in depression, although research findings remain inconsistent. This may indicate that distinct biological mechanisms underlie different symptom profiles in depressive episodes. GABA deficiency migh...

Machine learning provides individualized prediction of outcomes after first complete remission without allo‐HSCT consolidation in adult acute myeloid leukemia—A HARMONY study

Abstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a curative treatment option for a significant proportion of patients with acute myeloid leukemia (AML), and it is generally recommended when the relapse risk without allo‐HSCT outweighs the estimated non‐r...

Postmortem metabolomics as a window into the agonal phase of death: a comparison between opioid intoxications and hangings

Abstract Fatal opioid intoxications provide a postmortem diagnostic challenge due to a lack of coherent autopsy findings and the potential of tolerance and individual variations to complicate the evaluation of toxicological results. This study investigates whether postmortem meta...

Induction of type I and III interferons by viral and endogenous stimuli in systemic sclerosis

ABSTRACT Objective The interferon (IFN) system is activated in systemic sclerosis (SSc), but the driving mechanisms remain unclear. We asked whether type I and III IFN responses to Toll-like receptor (TLR)-7/8/9 stimulation of leukocytes from patients with SSc differ from healthy...

Neutrophil gelatinase-associated lipocalin (NGAL) is a poor diagnostic marker for sepsis in the ICU – An observational multicentre study

Abstract Background Sepsis is a major public health challenge, and reliable biomarkers are essential for distinguishing sepsis from other conditions. Neutrophil Gelatinase-Associated Lipocalin (Neutrophil gelatinase-associated lipocalin (NGAL)) has shown promise as a diagnostic m...

Prognostic value of risk factors for ischaemic and major bleeding events in chronic coronary syndrome: a SWEDEHEART registry study

AIM: In patients with chronic coronary syndrome, risk factors for ischaemic events and bleeding tend to overlap. However, the combined effects of these factors have scarcely been studied in contemporary real-world settings. METHODS: All patients in Sweden undergoing elective PCI...

Quantification of Urinary NGAL Using Volumetric Dried Urine Sampling

Objective: To evaluate the measurement of urinary neutrophil gelatinase-associated lipocalin (NGAL) from dried urine samples collected using Capitainer qDBS discs compared with liquid urine. Methods: Eighty urine samples from children aged 0–18 years were analysed. NGAL concentra...

The Right Key, the Wrong Lock: TIGIT Checkpoint Blockade and the Road to Precision Immunotherapy

T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT) emerged as one of the most promising next-generation immune checkpoint targets following the success of programmed cell death protein 1 (PD-1), programmed death-lig...

Impact of intraoperative CT on implant accuracy and reoperation rates in orbital floor reconstruction

BACKGROUND: Implant malposition is a leading cause of reoperation after orbital floor reconstruction. Intraoperative computed tomography (CT) enables immediate assessment and correction, however its impact on implant positioning accuracy and outcomes remains insufficiently studie...