Uppsala University Hospital

Induction of type I and III interferons by viral and endogenous stimuli in systemic sclerosis

ABSTRACT Objective The interferon (IFN) system is activated in systemic sclerosis (SSc), but the driving mechanisms remain unclear. We asked whether type I and III IFN responses to Toll-like receptor (TLR)-7/8/9 stimulation of leukocytes from patients with SSc differ from healthy...

Neutrophil gelatinase-associated lipocalin (NGAL) is a poor diagnostic marker for sepsis in the ICU – An observational multicentre study

Abstract Background Sepsis is a major public health challenge, and reliable biomarkers are essential for distinguishing sepsis from other conditions. Neutrophil Gelatinase-Associated Lipocalin (Neutrophil gelatinase-associated lipocalin (NGAL)) has shown promise as a diagnostic m...

Prognostic value of risk factors for ischaemic and major bleeding events in chronic coronary syndrome: a SWEDEHEART registry study

AIM: In patients with chronic coronary syndrome, risk factors for ischaemic events and bleeding tend to overlap. However, the combined effects of these factors have scarcely been studied in contemporary real-world settings. METHODS: All patients in Sweden undergoing elective PCI...

Quantification of Urinary NGAL Using Volumetric Dried Urine Sampling

Objective: To evaluate the measurement of urinary neutrophil gelatinase-associated lipocalin (NGAL) from dried urine samples collected using Capitainer qDBS discs compared with liquid urine. Methods: Eighty urine samples from children aged 0–18 years were analysed. NGAL concentra...

The Right Key, the Wrong Lock: TIGIT Checkpoint Blockade and the Road to Precision Immunotherapy

T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT) emerged as one of the most promising next-generation immune checkpoint targets following the success of programmed cell death protein 1 (PD-1), programmed death-lig...

Impact of intraoperative CT on implant accuracy and reoperation rates in orbital floor reconstruction

BACKGROUND: Implant malposition is a leading cause of reoperation after orbital floor reconstruction. Intraoperative computed tomography (CT) enables immediate assessment and correction, however its impact on implant positioning accuracy and outcomes remains insufficiently studie...