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Recent research
- Health & MedicineOpen access
Immunotherapy-Related Cardiac Arrythmias: Incidence, Pathobiology, Risk Factors and Management
Abstract Purpose of Review Immunotherapies have revolutionized treatment strategies for cancer patients, improving the prognosis in many populations with advanced malignancies. Immune check point inhibitors (ICI) and Chimeric antigen receptor (CAR) T cell therapy are being increa...
- Health & MedicineOpen access
Utility of the APE 2 Score as a Diagnostic Tool for Autoimmune Encephalitis
ABSTRACT Objective To retrospectively evaluate the diagnostic performance of the Antibody Prevalence in Epilepsy and Encephalopathy (APE 2 ) score relative to clinician‐adjudicated autoimmune encephalitis (AE) and the Graus criteria in a tertiary neuroimmunology referral cohort,...
- Health & MedicineOpen access
Obesity is common among people with HIV (PWH), yet evidence on weight loss with newer antidiabetic medications in this population is limited. We compared bodyweight change associated with glucagon-like peptide-1 receptor agonists (GLP-1RA), sodium–glucose cotransporter-2 (SGLT2)...
- Health & MedicineOpen access
Despite the significant contribution of poor perinatal mental health to maternal morbidity and mortality, mental health care is often overlooked and not prioritized during postpartum care in many developing countries. In a parallel randomized controlled trial in Ghana, we tested...
- BiologyOpen access
Abstract Progressive cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD). Dysregulation of calcium handling has been implicated in cardiomyopathy progression in DMD. Here we describe a therapeutic approach to improve calcium homeostasis in a mouse mo...
- Health & MedicineOpen access
Sexually Dimorphic Role of Estrogen Receptor α in Preserving Right Ventricular Endothelial Integrity
Abstract Right ventricular (RV) function and adaptation to afterload increase determine survival in pulmonary hypertension (PH). RV adaptation in PH is sexually dimorphic and more preserved in females, mediated by protective estrogen receptor α (ERα) signaling in cardiomyocytes....
- Health & MedicineOpen access
BACKGROUND: Lead testing in dried blood spots (DBS) offer a convenient alternative to venous blood draw; however, its adoption has been limited by variable extraction efficiency, matrix effects, and hematocrit-dependent recovery. To mitigate these challenges, we explored the util...
- Engineering & TechnologyOpen access
Abstract Background Humanistic practices offer many benefits in medical education. Compassionatomy, developed at University of California San Diego, incorporates humanistic compassion-cultivating practices into anatomy labs and was found to increase identification with body donor...
- Health & MedicineOpen access
Background Prosthetic joint infection (PJI) involves a significant mortality risk, with 26-30% of patients dying within 5 years. Current risk assessment tools offer limited prognostic accuracy for PJI patients. This study aimed to develop a prognostic model for 5-year all-cause m...
- Health & MedicineOpen access
Immune checkpoint inhibitors (ICIs) have transformed non-small cell lung cancer (NSCLC) therapy, but only 25% of patients have durable responses. TG4010, a mucin 1 (MUC1) vaccine, has demonstrated activity in NSCLC. We conducted a multi-institutional study to determine the safety...
- Society & EconomicsOpen access
Background There is increasing recognition that trauma exposure and related psychiatric consequences predict cardiovascular disease risk. However, most research has specifically examined post‐traumatic stress disorder—despite evidence that a range of psychiatric disorders may fol...
- Health & MedicineOpen access
Type 2 diabetes mellitus (T2DM) is a well-established risk factor for the development of heart failure (HF), yet HF risk within this population is highly heterogeneous. Appropriate biomarker selection and a limited mechanistic understanding of the phenotypic subtypes of HF in T2D...
- Health & Medicine
Perceived helpfulness of 56 treatment options in patients with chronic pain: a retrospective review
BACKGROUND: Chronic pain affects approximately 20% of US adults and often requires multiple treatment modalities. Although many therapies are available, less is known about which treatments patients perceive as helpful in real-world settings. METHODS: This retrospective cohort st...
- Biology
Abstract Cyclic peptides are powerful scaffolds for modulating protein–protein interactions; however, methods for constructing cyclic peptide libraries for cell-surface display applications remain limited. Here, we present a bacterial surface display platform that enables site-sp...
- Health & Medicine
Endovascular Thrombectomy for Cerebral Venous Thrombosis: Current Status and Future Directions
Abstract Cerebral venous thrombosis (CVT) represents a relatively rare cause of stroke, yet it carries an overall rate of death or dependency of up to 15%. The mainstay of its management is therapeutic anticoagulation, either subcutaneously or intravenously in the acute phase, fo...
- Health & MedicineOpen access
Reflux symptom burden and objective findings at long-term follow-up after peroral endoscopic myotomy
BACKGROUND: Peroral endoscopic myotomy (POEM) effectively treats achalasia but confers a significant risk of postoperative gastroesophageal reflux. Studies demonstrate poor short-term correlation between reflux symptoms and objective findings, but long-term outcomes remain unclea...