University School

Perceived helpfulness of 56 treatment options in patients with chronic pain: a retrospective review

BACKGROUND: Chronic pain affects approximately 20% of US adults and often requires multiple treatment modalities. Although many therapies are available, less is known about which treatments patients perceive as helpful in real-world settings. METHODS: This retrospective cohort st...

Bacterial Display of Genetically Encoded Macrocyclic Peptide Libraries Using Cysteine-Reactive Unnatural Amino Acids

Abstract Cyclic peptides are powerful scaffolds for modulating protein–protein interactions; however, methods for constructing cyclic peptide libraries for cell-surface display applications remain limited. Here, we present a bacterial surface display platform that enables site-sp...

Endovascular Thrombectomy for Cerebral Venous Thrombosis: Current Status and Future Directions

Abstract Cerebral venous thrombosis (CVT) represents a relatively rare cause of stroke, yet it carries an overall rate of death or dependency of up to 15%. The mainstay of its management is therapeutic anticoagulation, either subcutaneously or intravenously in the acute phase, fo...

Reflux symptom burden and objective findings at long-term follow-up after peroral endoscopic myotomy

BACKGROUND: Peroral endoscopic myotomy (POEM) effectively treats achalasia but confers a significant risk of postoperative gastroesophageal reflux. Studies demonstrate poor short-term correlation between reflux symptoms and objective findings, but long-term outcomes remain unclea...