University of Wisconsin–La Crosse

Global Transcriptional Differences in Staphylococcus aureus Biofilm-Associated Genes in a brpR Mutant Compared to Wild-Type Strain

Background: Staphylococcus aureus causes bloodstream and skin infections in humans. The prevalence of multidrug-resistant S. aureus strains means new antibiotics are needed. A novel antimicrobial drug named SK-03-92, a synthetic aromatic organic stilbenoid compound, kills S. aure...

MutFormer: a multimodal deep learning framework for predicting somatic mutation hotspots from sequence and chromatin features

Somatic mutations are unevenly distributed across the genome, with certain loci recurrently mutated across independent tumors. Both local DNA sequence context and chromatin organization have been associated with mutation rate variation, yet their combined effects at single-nucleo...