University of Wisconsin Health

Patient, care partner, and clinician perspectives on a “good day” with dementia

Abstract INTRODUCTION Outcome measures such as home time and institution‐free days have been proposed for use in intervention assessment among persons living with cognitive impairment (PWCI) and dementia. How well these measures capture perspectives on quality of life in dementia...

A randomized phase 2 placebo-controlled trial of clobetasol solution for oral chronic graft-versus-host disease therapy

Chronic graft-versus-host disease (cGVHD) affects multiple organ systems and frequently the mouth. There is an unmet need for more effective topical therapy to adequately control cGVHD in the oral cavity. Clobetasol is a super-potent synthetic glucocorticoid formulated here as an...

AI for Science: Reframing AI’s Role in Discovery

Abstract Digital computers have reshaped scientific practice, moving working scientific knowledge from printed texts into algorithms, simulations, and models. Advances in artificial intelligence (AI) are now accelerating that shift, progressing science in areas from protein foldi...

Isokinetic Quadriceps and Hamstring Peak Torque in Athletes Aged 10-50+: Preoperative Uninvolved Limb Reference Values for ACL Reconstruction

Background Current recommendations for quadriceps and hamstring peak torque normalized to body mass after anterior cruciate ligament reconstruction are derived from athletes in the second and third decades of life. There is a paucity of literature exploring the relationship betwe...

Plateau Pressure Exceeding Peak Inspiratory Pressure During Pressure Mode Ventilation With Active Inspiratory Effort

Background In patients receiving pressure modes of mechanical ventilation, plateau pressure can be higher than peak inspiratory pressure when the patient has a strong drive to breathe. This report provides comprehensive evidence to support this observation. Methods Peak inspirato...

Rhinosinusitis in Adults Receiving Tumor Necrosis Factor Alpha Inhibitors and Anti‐CD20 Therapy: A Scoping Review

ABSTRACT Introduction Immunomodulatory therapies, including tumor necrosis factor alpha (TNF‐α) inhibitors and anti‐CD20 agents, are often used for autoimmune, inflammatory, and neoplastic disorders. While infection risk is well recognized, their association with rhinosinusitis r...

Why Evidence Is Not Enough: Power, Politics, and a Strategy Shift for Public Health

Policy Points Public health has lost political influence because of a mismatch between the forms of power primarily deployed in this field—knowledge and moral authority—and the forms of power that currently shape societal rules and health outcomes—economic, political, ideological...

Prioritizing clinical utility to use allostatic load as a biomarker of the consequences of stress

Allostatic load measures the physiological consequences of stress and is associated with disease outcomes. Clinical use of allostatic load is limited, in part, because its calculation requires biomarkers not routinely measured in clinical care. Presently, we evaluated association...

Wisconsin State Comprehensive Planning Requirements are Associated with Better Local Planning for Healthy Eating and Active Living: A Multilevel Policy Content Analysis

Purpose To determine whether the specificity of mandates in Wisconsin’s state comprehensive planning statute is associated with the inclusion and actionability of healthy eating and active living items in local comprehensive plans. Design Retrospective, cross-sectional, multileve...

Cross-cultural adaptation and psychometric assessment of the Chinese version of the University of Wisconsin Running Injury and Recovery Index in runners

The University of Wisconsin Running Injury and Recovery Index (UWRI) is a nine-item patient-reported outcome measure assessing self-perceived running ability following running-related injury (RRI). This study aimed to translate and cross-culturally adapt the UWRI into Chinese and...

Predictive value of preoperative esophagram in postoperative outcomes after antireflux surgery

Abstract Background Gastroesophageal reflux disease (GERD) significantly impairs quality of life. Antireflux surgery (ARS) improves symptoms when medical therapy fails, but postoperative recurrence and dysphagia remain concerns, emphasizing the need for improved preoperative risk...