University of Warsaw

Acute toxicity and tissue deposition of graphene oxide decorated with platinum nanoparticles following intraperitoneal administration in rats

Recently developed novel graphene oxide decorated with platinum nanoparticles (GO/PtNPs) has been recognized for its anticancer properties. Therefore, in vivo studies assessing the toxicity and tissue deposition of these particles are needed. Using a fixed-dose acute toxicity des...

Inversion Problem in Algebras of Integrable Functions With Summable Fourier Transforms

ABSTRACT In this paper, we study the norm‐controlled inversion problem in two classes of algebras of integrable functions. In contrast of the classical case of , we prove that this problem has a positive solution in our setting without any additional restrictions.

Cholesterol-Enriched Membranes Reshape the Conformational Ensemble and Interfacial Mechanics of ACE2

Abstract Angiotensin-converting enzyme 2 (ACE2) is a type I transmembrane protein that functions as the primary entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 comprises a zinc-dependent extracellular domain (ECD) and forms homodimers, as res...

Rosavin, but not its combination with salidroside, lowers total β-catenin in human osteoblast cultures: an exploratory in vitro study under mineralizing conditions

Abstract Osteoblast dysfunction and altered Wnt/β-catenin-dependent responses accompany bone-remodeling imbalance in rheumatic and degenerative joint disease. Rosavin and salidroside are constituents of Rhodiola rosea preparations used without prescription, and are always encount...

Habit, choice, priming, and activity as flow: rethinking metaphorical models of action and cognition in cognitive linguistics

Abstract This article proposes a reconceptualization of action and cognition within Cognitive Linguistics (CL) by re-examining its foundational metaphorical models. While meaning in the field is often defined as embodied and usage-based, its dominant metaphors remain static, priv...

Demographic transition and the rise of wealth inequality

Abstract We analyse the contribution of rising longevity to the increase in wealth inequality in the U.S. over the past seventy years. To do so, we construct an overlapping generations (OLG) model with multiple sources of inequality, carefully calibrated to the data. Our key find...

Pandemonium free data for the JEFF-project

Abstract Reactor decay heat is due to the decay of both fission products and neutron activated fuel and reactor materials. At relatively short cooling times it is dominated by the beta decay of fission products. The calculation of the decay heat contribution of a particular fissi...

Global stability and uniform persistence in an epidemic model with saturating fomite-mediated transmission

Abstract We analyse the global dynamics of a Susceptible–Vaccinated–Exposed–Infected–Recovered (SVEIR) epidemic model with demographic turnover, imperfect vaccination, and two transmission routes: direct host-to-host contagion and indirect transmission via contaminated fomites. I...

Optically ResponsiveField-Effect Transistors Basedon Graphene/Diarylethene Hybrid Films

Abstract Photochromic molecules are emerging as key components in advanced optoelectronic systems owing to their ability to undergo reversible light-induced structural transformations that modulate their optical and electronic properties. Here, we investigate the optical response...

Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML

Acute myeloid leukaemia (AML) is a therapeutically challenging malignancy driven by the self-renewal, quiescence, and therapy resistance of leukaemic stem cells (LSCs). CDK8, a kinase component of the Mediator complex, regulates oncogenic transcription, and the selective CDK8/CDK...

Spectroscopic insights into HD 133729: Probing the physical parameters of the first blue large-amplitude pulsator (BLAP) in a binary system

HD 133729 (TIC 75934024) remains to this day the only spectroscopically confirmed binary system in which one of the stars is a blue large-amplitude pulsator (BLAP). The known distance to the system (${D\approx 480}$ pc) reveals that the BLAP component (the secondary) is not only...

eRASSU J043115.8-711730 The first pulsating symbiotic super-soft X-ray source in the Magellanic Bridge

Abstract The Magellanic Bridge stellar population is a relic of the tidal interaction between the Large and Small Magellanic Clouds. A comprehensive view of the evolution of the Bridge stellar population requires probing the compact remnants of stellar evolution, otherwise hidden...

Are components of the histone gene expression machinery functionally repurposed in terminally differentiated cells?

The expression of metazoan replication-dependent histone genes is controlled by NPAT and U7 snRNP. NPAT activates transcription of histone genes during S-phase, whereas U7 snRNP is a multi-subunit endonuclease that cleaves the resultant transcripts at the 3' end, yielding mature...

Exploratory SSR-Based Assessment of Genetic Diversity and Differentiation Among Four Wild Almond Populations in Kazakhstan

Wild almond relatives are valuable reservoirs of allelic variation for crop improvement and conservation, yet Kazakhstan’s wild-almond genetic resources remain poorly characterised. We conducted an exploratory SSR assessment of 80 putative individuals from four taxon-locality gro...