University of Victoria

Cell‐Type‐Resolved Proteomics Reveals Distinct Immune and Metabolic Programs Between Primary and Recurrent Ascites in HGSOC

ABSTRACT High‐grade serous ovarian carcinoma (HGSOC) frequently recurs after platinum–taxane therapy, yet recurrence‐associated changes within ascites remain unclear. We performed cell‐type‐resolved quantitative proteomics on paired ascites samples collected at primary diagnosis...

Regime Shifts and Transformations in Social-Ecological Systems: Advancing Critical Frontiers for Safe and Just Futures

Current research challenges in sustainability science require us to consider nonlinear changes—shifts that do not happen gradually but can be sudden and difficult to predict. Central questions are therefore how we can prevent harmful shifts, promote desirable ones, and better ant...

Stellar Interpretation of Meteoritic Data and PLotting for Everyone (SIMPLE): Isotope Mixing Lines for Six Sets of Core-collapse Supernova Models

Abstract Bulk meteorites and their inclusions exhibit, for many chemical elements, isotopic variability produced by nucleosynthetic events in stars and supernovae before the formation of the Sun. While the exact astrophysical origins of these variations are still a matter of deba...

Measuring Ocean Surface Waves

Abstract Propagating waves on the ocean surface can be represented as a stochastic process whose statistics are characterized by a spectrum. This paper reviews methods for measuring the wave spectrum and related quantities. Observations begin by sensing fluid dynamical properties...

Systematic review on the association between brain-related measures and upper limb movement characteristics after stroke

Abstract Background Upper limb (UL) movements are highly diverse, as are movement deficits following stroke. The relationship that stroke pathology has with UL impairments and their recovery has been studied with an increasingly complex array of neuroimaging and neurophysiology t...

Impact of soil and fluid physicochemical properties on erodibility: a review

Soil surface erosion, a process of removing earth materials such as soils or rocks by flows and/or waves, poses significant threats to the environment, infrastructure, and economy. The erodibility of soil is profoundly influenced by the physicochemical properties of both soil and...

Probabilistic Graphical Modeling for Machine Tool Dynamics with a Case Study in 3D Printer Vibration Compensation

Abstract This paper presents a new framework for modeling machine tool dynamics, aiming to enable their integration in machine tool digital twins. The framework is formulated as a Dynamic Bayesian Network, in which model parameters, sensor and process observations, and decision v...

LEMDO: Linked Early Modern Drama Online

LEMDO is a collaborative editing platform designed specifically for editing early modern drama by marking up files in TEI-XML and publishing those files as editions and anthologies. Our collective, collaborative mission is to create open-access, robust editions of early modern dr...

Machine learning–guided identification of determinants of PD-L1 expression and tumor mutational burden in lung squamous cell carcinoma

Programmed death-ligand 1 (PD-L1) expression and tumor mutational burden (TMB) are widely used immunotherapy biomarkers, yet their variability and determinants in lung squamous cell carcinoma (LUSC) remain incompletely characterized in real-world testing settings. We analyzed a r...