University of Toledo

Attitude and Medical Knowledge Among Medical Trainees and Physicians on the Transgender Population: A Multi-Institutional Survey

Objectives Despite a growing population of people who identify as transgender in the United States, existing healthcare and medical education systems have not all adapted to meet the needs of transgender people. Transgender individuals face persistent disparities in accessing hea...

TMAO at the Crossroads of the Gut–Brain Axis: Emerging Mechanisms Linking Microbiota-Derived Metabolites to Neuroinflammation and Cognitive Dysfunction

Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite produced through the hepatic oxidation of trimethylamine. Although TMAO has been widely investigated as a therapeutic target in multiple cardiovascular and metabolic diseases, growing evidence suggests it may pl...

Phenotypically diverse Klebsiella pneumoniae urinary tract infection isolates consistently cause pyelonephritis

ABSTRACT Urinary tract infections (UTIs) are a significant public health burden that impact millions of people every year and are highly prevalent among hospital-acquired infections. Klebsiella pneumoniae is globally the second most common cause of UTIs after uropathogenic Escher...

Adjuvant Systemic Hypothermia During Mechanical Thrombectomy (ReCCLAIM II): A Multicenter, Randomized, Controlled Trial

BACKGROUND: Hypothermia reduces ischemic injury in preclinical stroke models, yet translation into the clinical setting remains challenging. We aimed to assess the feasibility of inducing adjuvant systemic hypothermia among patients with large-vessel occlusion stroke during mecha...

The silent pandemic: the overlooked toll of stroke compared to COVID-19

The COVID-19 pandemic will be remembered as one of the defining health crises of the modern era. The World Health Organization reported approximately 7 million deaths attributed to COVID-19 globall...

Effect of cellulose nanocrystal reinforcement on erosion wear resistance of sisal/Areca/epoxy hybrid biocomposite

Cellulose nanocrystals (CNCs) have emerged as a promising bio-based reinforcing material and are widely used to enhance the performance of polymer composites. The present study investigates the effect of CNC reinforcement on the abrasive erosion wear behaviour of sisal/areca/epox...

Gut dysbiosis, blood pressure regulation, and cardiometabolic risk in polyendocrine metabolic ovarian syndrome (PMOS)

Abstract Polyendocrine metabolic ovarian syndrome (PMOS), formerly known as polycystic ovary syndrome (PCOS), is a common endocrine-metabolic disorder associated with increased hypertension and cardiometabolic risk. Gut dysbiosis is also frequently reported in affected women, rai...

Growth of aromatic hydrocarbon dust particles in the extremely metal-poor galaxy Sextans A

The mid-infrared spectrum of star-forming, high-metallicity galaxies is dominated by emission features from aromatic and aliphatic bonds in small carbonaceous dust grains, often referred to as polycyclic aromatic hydrocarbons (PAHs). In metal-poor galaxies, the abundance of PAHs...

Low acyl gellan gum supports bone tissue development and regeneration

Advances in bone tissue engineering depend on biomaterials that can promote osteogenic differentiation and matrix mineralization for functional bone regeneration. Gellan gum (GG), a naturally derived polysaccharide, which is biocompatible, has tunable gelation, and has potential...

A Comparison of Machine Learning Models for ICH Prognostication: An Analysis of ATACH-2 and Qatar Stroke Database

INTRODUCTION: Multiple prognostic scores have been developed to predict morbidity and mortality in patients with spontaneous intracerebral hemorrhage (sICH). These scoring models were traditionally based on statistical methods involving a limited set of variables. The advent of m...

Tuning of Aromatic Amine Polymer Side chains for Application as Hole Transport Materials in Wide-Bandgap Perovskite Solar Cells

Abstract Perovskite solar cells (PSCs) hold strong potential for efficient and cost-effective photovoltaic technology, yet their device performance and stability remain hindered by interfacial limitations. In particular, the hole transport material (HTM) that contacts both the pe...

Suzetrigine for Postoperative Pain in Head and Neck Free Flap or Transoral Robotic Surgery

Importance Postoperative pain after head and neck surgery frequently necessitates opioid analgesia despite multimodal pain regimens. Suzetrigine, a selective NaV1.8 inhibitor that was recently approved in the US for acute postoperative pain, may reduce postoperative opioid requir...

XID+PRIMA, II: Stepping Through Hyperspectral Imaging to Deblend PRIMAger Beyond the Extragalactic Confusion Limit

The PRobe far-Infrared Mission for Astrophysics concept aims to map large areas with spectral coverage and sensitivities inaccessible to previous FIR space telescopes, covering 25-235um. We synthesise images representing a deep imaging survey, with realistic instrumental and conf...

N-Acetylcysteine Attenuates Amikacin-Induced Biochemical, Inflammatory, and Histopathological Alterations in Mice

Background: Amikacin is an effective aminoglycoside antibiotic, but its clinical use is limited by nephrotoxicity, hepatotoxicity, and neurotoxicity. N-acetylcysteine (NAC), a glutathione precursor and antioxidant, may help reduce these side effects. This study evaluated whether...

“A New Partnership in the War on Drugs”: Detroit’s “Anti-Crackhouse Movement” and the Crime Politics of Community Development in the Black Power City

The arrival of community development corporations in cities across the United States in the 1980s marked an important development in the history of cities. CDCs were particularly appealing to Black mayors elected on police reform agendas in the 1970s, combining the rhetoric of lo...

Artificial intelligence in electrocardiogram interpretation for cardiovascular diagnosis and risk prediction: a systematic review of evidence through May 2026

Abstract Background Artificial intelligence-enabled electrocardiogram (ECG) analysis has expanded across cardiovascular diagnosis, monitoring, and risk prediction, but published studies vary in methodology, validation, and clinical applicability. We systematically reviewed AI app...

Na/K-ATPase Signaling in Adipocytes Promotes Atherosclerosis

BACKGROUND: Adipocyte dysfunction is closely associated with oxidative stress and chronic inflammation, which contribute to systemic metabolic disturbances and atherosclerosis. We previously identified the NKA (Na/K-ATPase) α1 subunit as a signal transducer that activates Src-fam...

Disparity in Clinical Presentation and Utilization of Atherectomy for Peripheral Arterial Disease: An Analysis of the OEIS National Registry

BACKGROUND: Racial and socioeconomic disparities exist in patients with peripheral arterial disease (PAD) and their treatment. We examined factors that may affect utilization of atherectomy in an office-based setting using a national outpatient registry. METHODS: Data were analyz...

SGLT2 inhibitors and secondary polycythemia: a systematic review and meta-analysis of hematologic effects in patients with type 2 diabetes

Abstract Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors are widely used in the management of type 2 diabetes mellitus (T2DM) due to their survival benefits. However, these agents are associated with increases in hemoglobin (Hgb) and hematocrit (Hct), raising concern...