University of the Philippines Diliman

PhosphoproteomicProfiling of Early-Stage Non-SmallCell Lung Cancer Provides Preliminary Evidence of Phosphorylation-RegulatedRho GTPase Signaling Driving Cytoskeletal Remodeling, Angiogenesis,and Cell Cycle Progression

Abstract Non-small cell lung cancer (NSCLC) is the primary cause of cancer-related deaths worldwide. This can be attributed to the difficulty in early detection and the limited efficacy of available treatments, partly due to an incomplete understanding of the disease biology. Ide...

From Neuropeptides to Toxins: Illuminating the Origins of Venom Complexity in Cone Snails

Abstract New genes and gene functions are key drivers of evolutionary innovation. Venomous animals, such as cone snails, provide striking examples of gene innovation, yet the mechanisms by which toxins arise remain poorly understood. Using the Conus textile genome, we uncover how...

Culturable Leptospira spp. exhibit no detectable spatial or matrix-associated structuring in Estero de Paco, Manila, Philippines

Leptospirosis is a globally important zoonotic disease that remains a major public health concern, particularly in tropical urban environments where flooding, inadequate sanitation, and high population density facilitate transmission. Despite its burden, the ecological and evolut...