University of Tampere

Polygenic risk for schizophrenia predicting age-specific fluctuations in depressive symptoms: Findings from the Young Finns Study

Background A well-established connection exists between psychoses and depression, with one presentation being depressive symptoms before psychosis. However, the predictive power of preceding affective symptoms is reported to be low, raising the question whether depressive symptom...

SOX10 Expression in Primary Salivary Gland Tumors: A Meta-Analysis

Abstract Purpose Primary salivary gland tumors form a heterogeneous group with diagnostic challenges. Sex-determining region Y-related homeobox 10 (SOX10) is a transcription factor studied in primary salivary gland tumors for over a decade. To date, no systematic review or meta-a...

Carbonic Anhydrases in Mycobacteria: Linking Metabolic Adaptation to Phenotypic Drug Tolerance

Abstract Tuberculosis (TB) treatment is increasingly challenged by both antimicrobial resistance (AMR) and phenotypic drug tolerance, the latter representing a reversible physiological state that contributes to persistence and prolonged therapy. While AMR is driven by heritable g...

A comparative study of physically activated biochars with multiple aqueous binders for sustainable supercapacitors

Electric double-layer capacitors were fabricated using CO 2 -activated carbons derived from three biochar precursors, two industrial Finnish biochars and an in-house willow biochar, combined with water-based chitosan and styrene-butadiene rubber/carboxymethyl cellulose binders. T...

Inequalities in sustainable ageing: functional mobility and depressive symptoms across migration subgroups among Russian-speaking migrants in Finland

Abstract Sustainable ageing depends on equitable opportunities to maintain physical, mental, and social well-being, yet older migrants are often treated as a homogeneous group. This study aimed to identify sociodemographic and migration-related subgroups among midlife and older R...

Catching the spark: The role of electrodermal activity in understanding teacher enthusiasm and students' lesson enjoyment

Abstract Process‐oriented approaches are needed to understand the temporality and dynamics of teacher–student interactions in higher education classrooms. In this study, we follow a complexity science approach, based on non‐linear intra‐ and inter‐personal physiology methods, to...

Automating clinical information retrieval from Finnish electronic health records using large language models

Abstract Clinicians often need to search for patient-specific information within electronic health records (EHRs) containing years of heterogeneous longitudinal documentation, a task that can be time-consuming, cognitively demanding, and prone to oversight. We evaluated 14 locall...

Linking acute exposure to future risk: an omics-to-AOP new approach method for next-generation risk assessment in a human in vitro lung air–liquid interface model

New approach methodologies (NAMs) are transforming chemical safety assessment by shifting focus from apical toxicity endpoints toward mechanistic, human-relevant prediction of adverse outcomes. Here, we present a human lung air-liquid interface (ALI) alveolar epithelial model cou...