University of St. Francis

External transportability of bacterial- and viral-associated host-response modules across public transcriptomic cohorts

Objectives To determine whether bacterial- and viral-associated whole-blood host-response modules discovered in GSE211567 retain their prespecified directions when applied unchanged to two external cohorts, including a second cross-platform cohort, and to quantify their robustnes...

A Better Winter

The submitted article presents a discussion on how various thinkers throughout history have viewed the aging process.

Barriers to birth preparedness and complication readiness in Tanzania: a narrative review through the lens of the Three Delays Model

Introduction Birth Preparedness and Complication Readiness (BPCR) is a key safe motherhood intervention aimed at reducing maternal and neonatal mortality through timely decision-making, delivery planning, and rapid response to obstetric emergencies. This narrative review synthesi...

Restrictome-EVOLVE: population-resolved haplotype architecture of human antiviral restriction-factor loci

Human antiviral restriction factors act across multiple stages of viral replication, but whether their population-resolved haplotype architecture differs systematically from comparable genomic regions is unclear. We tested this using phased public human genomic data from 660 indi...

Frameworks to identify research gaps, frame research needs, and derive research priorities from evidence syntheses:a scoping review

Objectives To identify and describe frameworks for systematically identifying research gaps from evidence syntheses, framing research needs, and establishing priorities, with emphasis on their use of GRADE (Grading of Recommendations Assessment, Development and Evaluation) certai...