University of South Carolina

A pair of chitosan receptors confer broad-spectrum fungal resistance

Chitosan, a major fungal cell wall component, activates plant immunity, yet the underlying perception mechanism remains unknown. In this study, we identified OsFID1, an apoplast-localized DUF26 domain protein, as a chitosan-binding receptor essential for chitosan-triggered immuni...

Mathematical simulations of paediatric haemodynamics in isolated ventricular septal defect

Computer modelling of the cardiovascular system has the potential to revolutionize personalized medical care. This is especially promising for congenital heart defects, such as ventricular septal defect (VSD), a hole between the two ventricles of the heart. However, relatively fe...

Shape Optimization for Incompressible Fluid Flows With Diffuse Domain Method

ABSTRACT Shape optimization plays a central role in scientific and engineering design, where one seeks to improve the performance of a system by altering its geometries subject to the governing partial differential equations (PDEs). This setting poses challenges for traditional n...

Social Network Theory in Behavior Change Interventions with Black Women to Reduce Inequities in Cardiovascular Health: A Scoping Review of Application and Measurement

Abstract Background Black women in the United States face disproportionate rates of hypertension and cardiovascular disease, driven by the compounding effects of structural inequity and socially embedded stress. Social networks are a critical and underutilized lever for health pr...

“My Existence is Queer”: Understanding Trans and Nonbinary College Students’ Sexual Identities

Scientific practices surrounding sexual identity are largely based upon cisheteronormative assumptions, using terms that may not resonate with − or may exclude − trans and nonbinary (TNB) individuals and their experiences. This exploratory study examined how TNB college students...

Epistemological Anatomy: A Conceptual Framework for Understanding Anatomical Knowledge

Anatomy is often regarded as settled knowledge. Yet anatomical propositions differ enormously in their evidentiary foundations, while textbooks and atlases frequently present them with similar certainty. How, then, does an anatomical observation become anatomical knowledge? We in...

Smart fitness equipment and subjective well-being: the roles of perceived value and brand love

Purpose Despite growing interest in artificial intelligence and smart technologies in sport and fitness centers, little is known about the psychological mechanisms through which smart fitness equipment promotes the well-being of fitness center members. Drawing on servicescape log...

Apc-deficient pituitary stem cells drive adamantinomatous craniopharyngioma through senescence-associated inflammation

Abstract Adamantinomatous craniopharyngiomas (aCPs) are complex intracranial neoplasms that arise in the sellar and suprasellar region of the brain, affecting the endocrine and nervous systems, causing severe sequelae. Although most of aCPs are driven by somatic mutations in β-ca...

Exclusive Breastfeeding Among Infants Younger Than 6 Months in Zambia

This cross-sectional study compares rates of exclusive breastfeeding among infants aged 0 to 5 months in Zambia, using data from 2013 to 2024, and disaggregates changes by infant, maternal, and geographic factors.

Friction in the looking-glass: public library worker perceptions of frictionless information standards

Purpose As a means of feeding a world increasingly hungry for information, emerging technologies have been designed to reduce, or even eliminate, friction. Frictionless mandates suggest that information should flow quickly and efficiently and that users should exert no more than...

Leveraging In Situ Chlorination for Resolving Subcellular Chlorinative Stress

Abstract Hypochlorous acid (HOCl) is a key effector in host defense, serving as a potent mediator of the innate immune response. However, dysregulation of HOCl production contributes to tissue damage and chronic inflammation. Existing HOCl indicators are constrained by limited co...

AI for research mathematics has arrived

Artificial intelligence can now solve research problems in mathematics and verify the answers

Breaking the Blend: A multi-tracer kinematic decomposition method for IFS data applied to disentangling the AGN outflow and circumnuclear ring in NGC 5728 with JWST

Abstract Integral field spectroscopy (IFS) of the central kiloparsecs of active galactic nuclei (AGN) reveals a mixture of spatially coincident emission from star-formation and AGN feedback exciting the interstellar medium. Disentangling these components remains a challenge, as m...

A structured taxonomy of autonomous manufacturing systems: Capabilities, definitions, and enabling technologies

Smart manufacturing has introduced adaptive, data-driven systems to the shop floor and beyond. However, current deployments operate near their technological limits, lacking the contextual adaptability, resilience, and independent decision-making required to manage unplanned disru...

Infant and early childhood mental health professionals’ attitudes toward a system of professional endorsement: A quantitative examination of personal factors, professional support, and perceived benefits

Abstract Demand for recognition of the specialized knowledge and skills required of Infant and Early Childhood Mental Health (IECMH) practitioners, researchers, and policymakers resulted in the establishment of standardized professional credentials that document this expertise. H...

Ethical and design considerations related to automated, confidential HIV testing invitations: insights from senders and recipients of SMS-based HIV testing invitations in Tanzania

Abstract Background Identifying individuals with undiagnosed HIV remains a global challenge. Mobile health (mHealth) approaches that leverage social networks hold potential to increase HIV testing uptake but also raise ethical considerations. Methods We conducted a qualitative st...

Grief in Neurosurgery: Reframing Loss and Identity Through Lived Experience.

Grief is an under-recognized yet pervasive experience in neurosurgery, arising not only from the death of patients and loved ones but also from losses related to professional identity, health, and personal relationships. Despite its relevance, grief is often conflated with burnou...

Genome mining of the tumor microbiome reveals biosynthetic diversity and potential pathology-modulating metabolites

Human tumor-associated microbes – the tumor microbiome – have demonstrated an increasingly important role in human health due to their relevance to cancer progression and treatment response. While the metabolism at the host-microbiota interface, such as in the human gut, has been...

Building trust, bridging traditions: a story of collaborative instructional planning in a high school-university partnership

Purpose This article documents the collaboration between a high school social studies teacher and a university professor – working within an existing school-university partnership – in the design and implementation of a geography-based Holocaust lesson to support authentic learni...

Divination and Danger in the Festival of Indra’s Banner

Abstract This article centers on an analysis of the structure of the medieval Hindu festive ritual of “Indra’s Banner” ( indradhvaja ), using the canonical account of the sixth-century astrologer-astronomer Varāhamihira ( Bṛhatsaṃhitā 42). After situating the ritual within the br...