University of Shizuoka

Clinical applicability of cystatin C-based renal function assessment and HPLC-based therapeutic drug monitoring for predicting cefepime overexposure

Abstract Background Cefepime (CFPM)-associated neurotoxicity is linked to elevated plasma concentrations, particularly in patients with impaired renal function. Although cystatin C-based estimated glomerular filtration rate (eGFRcys) has been proposed as a potentially superior ma...

Association of medical visit frequency with cardiovascular events and mortality in patients with dyslipidaemia: a cohort study using a Japanese claims database

Abstract Background Dyslipidaemia is a major risk factor for cardiovascular and cerebrovascular diseases; however, the optimal frequency of medical visits remains unclear. Objective To examine whether medical visit frequency is associated with the incidence of cardiac events, cer...

Standardization of shotgun metagenomics parameters for pks-positive enterobacteria detection in human fecal samples: Receiver operating characteristic analysis using polymerase chain reaction as reference standard

Enterobacteria harboring the polyketide synthase ( pks ) island ( clbA – clbS ), which encodes colibactin ( pks⁺ enterobacteria), is a putative risk factor for colorectal cancer. Polymerase chain reaction (PCR) is the current standard for detection. Primer-independent shotgun met...