University of Regensburg

The first RNAi ‐based biopesticide approved in the United States: regulatory implications for the European Union – the case of Ledprona (Calantha™)

Abstract RNA interference (RNAi), a naturally occurring gene‐silencing mechanism, has emerged as a promising platform for developing innovative, non‐genetically modified (GM) plant protection products. In the context of climate change, biodiversity loss, and growing resistance to...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Metabolic plasticity supports a flexible nutritional symbiosis in Cardiocondyla ants

Abstract Nutritional symbioses have repeatedly evolved in insects, yet how hosts regulate these partnerships to balance benefits across development and environments remains unclear. Ants provide an exceptional system to address this question, as several lineages maintain ancient...

Electron-Donor–AcceptorEnabled ElectrophilicC(sp2)-C(sp3) Cross-Coupling

Abstract The construction of C(sp2)-C(sp3) bonds is fundamental to pharmaceutical synthesis, yet metal-free approaches to electrophilic cross-coupling remain underdeveloped. Herein, we report a visible-light-driven, metal-free cross-coupling between heteroaryl nitriles and alkyl...

Exploring the association between genetic polymorphisms in FGFR2 and children’s facial morphology

Abstract Background Studies on animal models and fibroblast growth factor receptor (FGFR2)-associated craniosynostosis syndromes suggest that FGFR2 plays a crucial role in craniofacial development. Therefore, the present exploratory study aims to investigate the relationship betw...

FastRet: Fast andSimple Retention Time Predictionin Liquid Chromatography

Abstract Feature annotation in liquid chromatography–mass spectrometry (LC–MS)-based untargeted metabolomics remains challenging. Retention time (RT) prediction can support candidate prioritization and improve annotation confidence. Here, we present FastRet, an R package predicti...

Category-based attention facilitates the recognition of actions

Abstract Action recognition relies on efficiently prioritizing relevant sources of information. This study examined the degree to which category-based attention facilitates the identification of basic action categories (climb, jump, run, walk) depicted as static avatar images (Ex...

Strain-release photocatalytic access to rigidified isosteres of bicyclic heterocycles

We present the synthesis of fused isoxazolidine-pyrrolidine architectures via a dual rigidification strategy. These frameworks are accessed through an atom-economical approach using variously substituted isoxazolines and bicyclo[1.1.0]butane (BCB) derivatives under mild condition...