University of Regensburg

Clickable Turn-On Nanoparticles for Target-Specific Intracellular Activation

Abstract Precise visualization of nanoparticles (NPs) at the subcellular level is crucial for targeted drug delivery. However, NPs functionalized with permanently fluorescent probes are challenging to detect when only a small fraction reaches the target compartment, as weak fluor...

Learning to stabilize nonequilibrium phases of matter with active feedback using partial information

Abstract Recent advances in quantum computing experiments have enabled new pathways for feedback control. Here, we investigate the role of information in interactive quantum many-body dynamics to engineer out-of-equilibrium phases of matter. To this end, we train reinforcement le...

Visible‐Light Cobalt‐Catalyzed Synthesis of Aroyl Amides From Arylazo Sulfones

A versatile strategy leveraging the peculiar reactivity of arylazo sulfones as substrates bearing dyedauxiliary groups in arylation processes, combined with the catalytic activity of Co 2 (CO) 8 in carbonylation reactions, enabled the efficient synthesis of aromatic amides. The p...

Disease Duration Differentiates Freezing of Gait Response to Subthalamic and Nigral Stimulation for Parkinson's Disease in an Exploratory Multicenter Controlled Trial

BACKGROUND: Freezing of gait (FoG) belongs to most pressing unmet symptoms in the treatment of Parkinson's disease. OBJECTIVES: To explore whether combined subthalamic and nigral (STN + SNr) deep brain stimulation improves FoG compared with optimized STN stimulation alone; to ide...

Molecular characterization of colorectal cancer liver metastases with pure desmoplastic versus non-pure desmoplastic histopathological growth patterns using a targeted gene expression panel

The histological growth pattern (HGP) at the interface of colorectal adenocarcinoma liver metastases (CRCLM) and liver parenchyma provides important prognostic information. This study aimed to identify transcriptomic signatures underlying the predominant HGPs in CRCLM. We retrosp...

Navigating the Radical Oxo‐Functionalization of Alkenes Toward Ketones

Ketones are ubiquitous structural motifs in pharmaceuticals, natural products, agrochemicals, and functional materials, as well as indispensable building blocks in organic synthesis. This outlines the design of efficient carbonyl‐forming strategies a crucial target in methodology...

From Classification to Cross-Modal Understanding: Leveraging Vision- Language Models for Fine-Grained Renal Pathology

Fine-grained glomerular subtyping is essential for kidney biopsy interpretation, yet it presents a harder setting than the broad organ- or disease-level recognition tasks commonly used in vision-language model (VLM) evaluation. In this task, all categories arise within the same r...

MOSAIC: Intra-tumoral heterogeneity characterization through large-scale spatial and cell-resolved multi-omics profiling

Understanding the tumor microenvironment has the potential to significantly advance precision oncology, but this effort has been hampered by the scarcity of consistent large data sets. Here, we introduce MOSAIC (Multi-Omics Spatial Atlas in Cancer), a multi-center clinical omics...

Diagnostic value of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in staging histological subtypes of invasive bladder cancer

Abstract This study assessed the diagnostic value of [ 18 F]FDG-PET/CT in staging histological subtypes (HSs) of invasive bladder cancer. In 112 patients with ≥ 75% HS-content, 87% of primary tumours were FDG-avid, 9% were non-assessable (due to high FDG-avid urine), and only 5%...

A crystalline uranium Fischer-type carbyne

Abstract Since their discovery in 1973, transition metal Fischer carbynes have become a foundational class of metal–carbon triple bond in organometallic chemistry. However, even though the uranium Fischer carbyne bonding motif has been a fundamental target in f -element chemistry...

Comparison Between Skeletally‐Anchored and Conventional Maxillary Protraction in Growing Class ΙΙΙ Patients: A Systematic Review and Meta‐Analysis

ABSTRACT Objective The aim of this systematic review was to evaluate the skeletal and dental effects of skeletally‐anchored (SA) maxillary protraction compared with conventional facemask (FM) therapy in growing patients with Class III malocclusion, while controlling for the confo...

Executing discrete/continuous declarative process specifications via complex event processing

Abstract Traditional Business Process Management (BPM) focuses on discrete events and fails to incorporate critical continuous sensor data in cyber-physical environments. Hybrid declarative specifications, using Signal Temporal Logic (STL), address this limitation by allowing con...

Enceladus-like geochemistry fuels methanogenesis under extreme CO 2 limitation

Saturn’s icy moon Enceladus features chemical signatures consistent with an alkaline soda ocean with H 2 production via hydrothermal water-rock reactions. Chemolithoautotrophic methanogenesis is thermodynamically favorable under these conditions, but it is unknown whether CO 2 sc...

Actin conformation dynamics precede force generation in cytotoxic T lymphocytes

Abstract Cytotoxic T lymphocytes (CTLs) are cells of the adaptive immune system that are able to recognise and kill cancerous or virally infected target cells. The biochemical basis of CTL-mediated killing has been examined in great detail. Recent work has underscored the importa...

Cutaneous Deterioration Following Glucocorticoid Discontinuation in Psoriatic Arthritis: A Real-World Cohort Study

Background/Objectives: To evaluate the frequency of documented cutaneous deterioration within three months after complete discontinuation of systemic glucocorticoid therapy in psoriatic arthritis (PsA) and to assess a potential association with cumulative glucocorticoid exposure....

Coverage and adherence to the German childhood vaccination schedule: results from the KUNO-Kids health study

In Germany, the childhood vaccination schedule in 2015–2020 included 13 vaccines, for which primary immunization series was recommended to be completed by 24 months of age. Childhood vaccination coverage is monitored through health insurance claims data and pre-school entry exami...

NHC‐Copper(I)‐Mediated Functionalization of White Phosphorus

ABSTRACT We report a method for converting white phosphorus (P 4 ) directly into tetra‐ and pentaphosphanes using N ‐heterocyclic carbene (NHC) copper(I) complexes. The insertion of P 4 into the metal‐element bonds of the NHC complexes (6Dipp)Cu(Nu) [Nu = O t Bu and N( i Pr) 2 ]...

Tunable Kondo Behavior in a Bilayer Graphene Quantum Channel

Abstract The interaction between itinerant electrons and localized spins is key to a wide range of electronic phenomena. We present conductance measurements of a quantum point contact (QPC) in bilayer graphene (BLG). Beyond the expected quantized conductance plateaus reflecting s...

Factors associated with drug adherence in psoriasis: a single‐center, retrospective, questionnaire‐based exploratory study in Bavaria

BACKGROUND AND OBJECTIVES: Achieving sustained drug adherence in psoriasis remains challenging despite effective therapies. This exploratory study aims to investigate the care situation and factors associated with drug adherence in patients with moderate-to-severe psoriasis vulga...

„Follow the Science“? Die Blindstellen der (deutschen) Politikwissenschaft in Fragen von Krieg und Frieden

Zusammenfassung Der Beitrag analysiert Fachtrends und Strukturentwicklungen der Disziplin Internationale Beziehungen (IB) und beleuchtet dabei insbesondere die Lage in Deutschland. Er geht der Frage nach, welchen Wert die in jüngerer Zeit vom Fach hervorgebrachten Erkenntnisse fü...