University of Puget Sound

Shared and distinct gain-of-function consequences from pathologic cytoplasmic versus nuclear TDP-43

Abstract While predominantly nuclear localized in healthy cells, TDP-43 can transit between the nucleus and cytoplasm. In frontotemporal lobar degeneration (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), TDP-43 accumulates in hyperphosphorylated cytoplasmic aggregates. Howeve...