University of Pennsylvania Health System

Early Adoption and Diffusion of Oral Semaglutide in US Adults With Obesity

This cohort study evaluates early treatment trends of oral semaglutide among adults eligible for obesity management medications following its approval for obesity.

No difference in alloimmunization of pregnant adults with sickle cell disease exposed to chronic versus on‐demand transfusions: A two‐center retrospective cohort study

Abstract Background Pregnant people with sickle cell disease (SCD) experience high morbidity and mortality, even when RBC transfusion is safe and available. There is a lack of consensus on transfusion use partly due to concern for alloimmunization. This study examined alloimmuniz...

Comparative Efficacy of Embolic Agents for Single-Session Meningeal Artery Embolization and Surgical Evacuation: Evaluating Liquids, Particles, and Adjunct Coils

BACKGROUND AND OBJECTIVES: Single-session middle meningeal artery embolization (MMAE) combined with surgical evacuation is an emerging strategy for management of patients with chronic subdural hematoma (cSDH). However, comparative outcome data based on embolic material selection...

Epidemiology of Health-Related Social Needs Screening and Positivity in a Multistate Health System

Importance: Health systems increasingly screen for health-related social needs (HRSNs), which are modifiable social factors associated with health outcomes. However, screening selection biases and HRSN burdens are poorly characterized. Objective: To evaluate patient characteristi...

The Effects of Street Cleaning on Serious Crime and Gun Violence in Philadelphia, 2023-2024: A Stratified Randomized Controlled Trial.

. 2026;116(8):1171-1179. https://doi.org/10.2105/AJPH.2026.308429).