University of Oklahoma Health Sciences Center

Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients

Importance Female patients undergoing cardiac surgery have a higher transfusion burden, yet they remain underrepresented in randomized clinical trials. Although the ANH trial showed no significant reduction in the proportion of patients receiving allogeneic blood transfusions wit...

Trends in Ophthalmic Hospital Transfers and Consultations Across US Academic Centers

Importance Academic medical centers increasingly serve as a safety net for urgent and complex ophthalmic conditions, yet trends in the demand for hospital-based ophthalmic services remain poorly characterized. Objective To characterize multi-institutional trends in ophthalmology...

Triphenylphosphonium compounds preferentially inhibit long-chain fatty acid oxidation in cardiac mitochondria

Triphenylphosphonium (TPP) is a lipophilic molecule widely used in targeting compounds into the mitochondria. Despite its wide use, TPP has known mitochondrial toxicity, the characteristics of which are not completely defined. In this study, we sought to determine if the effects...

One-year cancer incidence following acute ischemic stroke: a retrospective propensity-matched multi-center cohort study

Acute ischemic stroke (AIS) and cancer share overlapping pathophysiologic mechanisms, and stroke survivors may face an elevated short-term risk of incident malignancy, but population-level estimates remain limited. We conducted a retrospective cohort study using the TriNetX US Co...

Physician- and Practice-Level Variation in Clinical Trial Participation Among Patients With Advanced Cancer

Importance Clinical trial enrollment is essential to advancing cancer care, yet participation among patients with advanced cancer remains low. While patient-level barriers are frequently cited, the role of health care delivery factors—specifically physician- and practice-level va...

Comparative Effectiveness Research in the Americas on Penetrating Brain Injury: The COMPAS-PBI Study Protocol.

BACKGROUND AND OBJECTIVES: Penetrating brain injury (PBI) is a highly lethal form of traumatic brain injury, with substantial mortality and marked differences across high-income countries and low- to middle-income countries. The aim of the Comparative Effectiveness Research in th...

Trends in Regionalization of Pediatric Inpatient and Critical Care by Medical Complexity

BACKGROUND AND OBJECTIVES: Pediatric inpatient and critical care services are increasingly regionalizing: shifting from smaller hospitals to larger specialty centers. Children with medical complexity (CMC) and with technology dependence (TD) account for a disproportionate share o...

Stepwise pairing and fast transition regulated by recombination drive meiotic chromosome interactions

Maternal and paternal homologous chromosomes recognize each other and pair during meiosis to ensure accurate chromosome segregation. However, the mechanisms that drive chromosome pairing and their regulation remain poorly understood. To investigate this, we develop a fluorescence...

PFKFB2 Gates a Relationship Between Cardiac Glycolytic Regulation and Electrophysiological Function

Abstract Background The cardiac isoform of phosphofructokinase-2/fructose 2,6-bisphosphatase (PFKFB2) is the heart’s strongest glycolytic regulator but is degraded in the absence of insulin signaling. This makes PFKFB2 loss critical to understand in metabolic heart disease, of wh...

Age-Associated Cognitive Deviations in Early-Onset Psychosis Patients and Their Siblings

OBJECTIVE: The objective of this study was to test for cognitive impairments and cross-sectional age-associated cognitive deviations in a large, diagnostically diverse, cross-sectional sample of children and adolescents with early-onset psychosis (EOP), their siblings, and nonpsy...

Hereditary TTP and Hemolytic Anemia in Newborns

Hereditary thrombotic thrombocytopenic purpura (hTTP) is a thrombotic microangiopathy due to severe ADAMTS13 deficiency. hTTP typically presents in adulthood with thrombocytopenia, hemolytic anemia, and/or neurologic abnormalities. However, nearly half of the patients with hTTP a...

Improbable healing in endodontics: a case series of favorable outcomes despite adverse prognostic conditions

Endodontic prognosis is based on clinical and radiographic factors that estimate the likelihood of treatment success. Because periapical healing reflects complex interactions among microbial, host, anatomical, and treatment-related factors, individual outcomes may occasionally di...

Engineering of OHet72 Nanocrystals into Nanostructured Microparticles for Pulmonary Delivery of a Novel Antitubercular Drug Candidate

Background/Objectives: Current treatments for tuberculosis (TB) are complex and associated with severe side effects; thus, drugs with minimal side effects would be desirable as additions to current therapies to combat the global TB epidemic. OHet72 is a novel compound with in vit...

Bridging gaps in future healthcare professionals’ understanding of justice-related healthcare

The impact of mass incarceration extends beyond the isolated experiences of justice-involved individuals and has a reaching, multifactorial impact on the health of society. Healthcare providers must be prepared to treat patients who are returning from carceral facilities. Unfortu...

Application of [ 18 F]NaF and [ 18 F]FDG PET/CT to Assess Molecular Calcification and Glucose Metabolism in Thyroid Cartilage

Objective Thyroid cartilage calcification and glucose metabolism may vary with age and gender. This study investigated the role of [ 18 F]-sodium fluoride ([ 18 F]NaF) and 2-[ 18 F]fluoro-2-deoxy-D-glucose ([ 18 F]FDG) PET/CT in evaluating of physiological molecular calcification...

Mobile Cardiac Rehabilitation for Older Adults With Ischemic Heart Disease: A 12‐Month Follow‐Up on Hospital Readmissions in the RESILIENT Trial

Kaplan-Meier analysis of time to first all-cause readmission over 12 months among older adults with ischemic heart disease randomized to 3 months of mobile health cardiac rehabilitation (mHealth-CR) or usual care. There was no significant difference in time to first readmission b...

Safety and Effectiveness of a Novel Dual-Energy Radiofrequency/Pulsed Field Ablation Catheter: 12 Month Results of the FlexPulse Study

BACKGROUND AND AIMS: Pulsed field (PF) ablation is increasingly used to treat paroxysmal atrial fibrillation (PAF). FlexPulse (NCT06676072) was conducted to evaluate safety and effectiveness of a novel dual-energy, flexible-tip focal ablation catheter with radiofrequency and PF f...

Crucial role of telomere maintenance-related genes in survival prediction and subtype identification in colorectal cancer

Abstract Telomere maintenance genes are closely related to colorectal cancer (CRC) development and progression. However, the potential influence of telomere maintenance-related genes (TMRGs) on the prognosis of CRC and their clinical relevance remains insufficiently explored. Uti...

Side-to-Side versus Traditional End-to-Side Approach to STA-MCA Bypass in Moyamoya Disease: A Comparative Meta-Analysis

Background Superficial temporal artery to middle cerebral artery (STA-MCA) bypass is a standard-of-care treatment for adult patients with moyamoya disease (MMD). Although the classical technique is end-to-side (E-S) bypass, the side-to-side (S-S) construct has emerged as an alter...

Mitophagy and Noncoding RNA Regulation in Type 2 Diabetes Mellitus: Molecular Mechanisms, Tissue-Specific Evidence and Translational Perspective

Despite significant therapeutic advances, T2DM remains a global public health challenge that leads to multiple complications, including cardiovascular, renal, hepatic, and neurodegenerative disorders. Mitochondrial dysfunction and impaired mitophagy remain fundamental, yet incomp...