University of Occupational and Environmental Health Japan

Sodium–Glucose Cotransporter 2-Mediated Glucose Uptake Contributes to Glycogen Accumulation in Clear Cell Renal Cell Carcinoma: Implications for Clear Cell Morphology and Potential Therapeutic Relevance

Clear cell renal cell carcinoma (ccRCC) is characterized by loss of the functional von Hippel–Lindau (VHL) complex and distinctive clear cell morphology associated with intracellular glycogen and lipid accumulation. However, the mechanism underlying glycogen storage remains uncle...

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

Systematic review and network meta-analysis of performance of the Sapporo criteria, the Revised Sapporo criteria, and the 2023 ACR/EULAR APS classification criteria for patients with antiphospholipid syndrome: A protocol

Background Antiphospholipid syndrome is an autoimmune disorder characterized by recurrent thrombotic events and/or adverse pregnancy outcomes. Although three classification criteria—the 1999 Sapporo criteria, the Revised Sapporo criteria, and the 2023 ACR/EULAR antiphospholipid s...

Cesarean delivery and overweight at 6 years of age: a prospective cohort analysis of the Japan Environment and Children’s Study

Abstract Cesarean delivery (CD) has been suggested as a potential risk factor for childhood overweight and obesity; however, evidence beyond early childhood remains inconsistent. We examined the association between CD and childhood overweight at age 6 years and explored early lif...

Perioperative Durvalumab for Resectable NSCLC : Updated Outcomes for Japanese Patients in AEGEAN

ABSTRACT In the phase 3 AEGEAN study, perioperative durvalumab plus neoadjuvant chemotherapy significantly improved the primary endpoints of event‐free survival (EFS) and pathological complete response (pCR) in patients with resectable NSCLC versus neoadjuvant chemotherapy alone....

Protein–protein interaction network-based evaluation of lung cancer relevance and hub gene identification from in vitro crocidolite exposure signatures

Abstract Objectives This study evaluated whether a protein–protein interaction (PPI) network-based approach can link in vitro exposure-induced gene expression signatures to human disease modules. Methods Crocidolite, a well-established lung carcinogen, was used as a model of inha...

Cassini CDA observes compositional segregation of Enceladus’ ice grains from slow freezing and fragmentation of oceanic spray

Salt-rich ice particles, termed Type 3, are a major compositional group within Enceladus’ plume and Saturn’s E ring and are thought to represent frozen micrometer-sized aerosolized droplets of Enceladus’ salty subsurface ocean. Here, we present an analysis on the basis of ≈1000 m...

Prognosis and risk factors by histologic type of malignant ovarian germ cell tumors in Japan: a JSOG gynecologic tumor registry-based study

Objective: This study evaluated prognosis and risk factors for overall survival (OS) in malignant ovarian germ cell tumors (MOGCTs) using data from the Japan Society of Obstetrics and Gynecology tumor registry.Methods: Data from 1,538 MOGCT patients (2004MOGCT patients ( -2019) )...

Multi-mode design for studying cyber aggression in texts, Facebook and Twitter messages among middle school youth

With the explosion of the internet, cyber aggression has become one of the fastest growing forms of interpersonal violence. Methods used to understand aggressive communications content have been limited primarily to surveys. Here, we present multiple methods - panel surveys, elec...

Associations between the number of healthy lifestyle habits and focus on opportunities among Japanese workers: a cross-sectional study

In the context of an aging workforce, sustaining workers’ occupational future perspectives is increasingly important. Focus on Opportunities (FOO), a subscale of Occupational Future Time Perspective, reflects workers’ beliefs about future goals and possibilities in their careers...

Evaluation of clinical prognostic factors for radium-223 therapy in castration-resistant prostate cancer with bone metastases: the KYUCOG-1901 study

We evaluated clinical factors associated with symptomatic skeletal events (SSEs), radiographic progression-free survival (rPFS), and overall survival (OS) in patients with metastatic castration-resistant prostate cancer (mCRPC) and bone metastases treated with radium-223 (Ra-223)...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Long-term risk factors for hemophilic arthropathy in patients with severe hemophilia A: a 36-year retrospective cohort study

Hemophilic arthropathy (HA) is a major cause of disability in patients with severe hemophilia A. However, long-term data describing progression to advanced radiographic HA across major joint sites remain limited. We investigated risk factors for progression to advanced HA over ex...