University of Notre Dame

Reactions of Terminal Olefins With Iron Carbenes

ABSTRACT The application of sustainable, earth‐abundant iron complexes to the olefin metathesis of terminal olefins remains a formidable challenge due to competitive, metathesis‐divergent deactivation pathways. Herein, we investigate the reactivity of pincer‐supported iron carben...

Dispatch or Hold? An Inverse Optimization and Reinforcement Learning Approach for Multiobjective On-Demand Delivery

In large-scale on-demand food delivery systems, dynamic order dispatching needs to balance immediate dispatch and order holding amid competing objectives, including delivery efficiency, service timeliness, and courier utilization. Holding certain orders for future consolidation m...

Founder Narcissistic Admiration and Young Firm Performance: The Mediating Role of Innovative Ambidexterity

Abstract Personality characteristics of entrepreneurial leaders appear to play an important role in facilitating the kinds of innovative activities that enhance young firm performance. Scholars have highlighted the need for these firms to demonstrate innovative ambidexterity, or...

An Intelligent Design Methodology for Morphing Structures Under Winds

Civil infrastructure is vulnerable to extreme winds that pose threats to its safety, habitability and serviceability issues that potentially threaten life, human comfort and property. The burgeoning growth of mega urban areas with clusters of tall buildings are facing these chall...

Physioxia Reprograms Glioblastoma Cells Enhancing Migration and Altering Therapeutic Sensitivity

Abstract Background/Objectives Glioblastoma is an aggressive primary brain tumor that develops within a chronically low-oxygen microenvironment, yet most preclinical studies are performed under atmospheric oxygen conditions that poorly reflect in vivo physiology. This study inves...

A novel bone and cancer cells co-culture methodology to model breast cancer metastasis to bone ex vivo

One of the major challenges in late-stage cancer research is studying the direct interactions between cancer cells and the metastatic tissue. Metastasis is an inefficient multistep process in which only a small subset of cancer cells successfully colonizes the new microenvironmen...

Longitudinal changes in gut microbiota across reproductive states in wild baboons

Background: In humans and other mammals, female reproduction is linked to extensive changes in physiology, immunity, hormones, and behavior. These changes likely shape, and may be shaped by, the composition of gut microbial communities. Characterizing the dynamics of gut microbia...

Transcriptomic insights into age-associated extracellular matrix promotion of breast cancer

Aging is a key risk factor for breast cancer; however, the independent effects of the aged extracellular matrix (ECM) remain understudied. To address this, we developed a novel hybrid in vivo model that enables the independent investigation of age-related ECM influences on breast...

Using insertable cardiac monitors to test determinants of heart rate and activity in captive baboons

Insertable cardiac monitors (ICMs) provide fine-grained, continuous data on cardiac activity. These data have great potential to reveal individual physiology, energetics, and stress responses, with implications for animal health, cognition, welfare, and conservation. However, the...

Indoor neutral-host networks over shared spectrum and shared infrastructure: a comparison study of real-world deployments

Abstract Indoor high-capacity connectivity is often constrained by significant building penetration loss and uplink power limitations of outdoor macro-cells. While Mobile Network Operators (MNOs) optimize low-band (<1 GHz) and mid-band (1–7 GHz) spectrum, uplink performance re...