University of Nairobi

Polycyclic Aromatic Hydrocarbons in Kenyan Coral Reef Sediments: Distribution, Sources, and Equivalent Ecological Risks

This study evaluated the spatial distribution, source apportionment, and equivalent ecological risk of polycyclic aromatic hydrocarbons (PAHs) in 18 surface sediments across four Kenyan coral reef ecosystems (Malindi, Watamu, Kilifi, and Mombasa-Nyali). Total PAH concentrations (...

Supply chain antifragility capabilities: a systematic literature network analysis and conceptual framework

Purpose Supply chains are essential to economic growth in many industries. However, their complexity and slow response to market changes leave them vulnerable to environmental disruptions. The concept of antifragility explains how organizations can withstand and even thrive durin...

Enantioselective Benzylic C–H Insertions with Diazosuccinate Esters

Abstract The first enantioselective benzylic C–H insertion using α-alkyl-α-diazoesters, facilitated by a well-established chiral dirhodium(II) catalyst, is presented. This reaction selectively functionalizes primary benzylic C–H bonds with good to excellent enantioselectivity (up...

Sub-national estimates of visceral leishmaniasis and optimisation of geographical accessibility to treatment centres in Kenya

Abstract Background Visceral leishmaniasis (VL) remains a major public health challenge in Kenya, disproportionately affecting populations with limited access to timely diagnosis and treatment. National case totals mask local heterogeneity in risk and access. Here we estimate sub...

Market waste composition, biomethane yield, and energy potential in Nairobi, Kenya

Introduction: Municipal solid waste (MSW) management remains a critical sustainability challenge in rapidly urbanizing cities, particularly in Sub-Saharan Africa where inadequate infrastructure and reliance on unsanitary landfills exacerbate greenhouse gas emissions. Nairobi, Ken...

Enablers and barriers to Electronic Community Health Information System (eCHIS) usage in Kenya: A Work System Framework Analysis of frontline health worker experiences

Introduction The Electronic Community Health Information System (eCHIS) is Kenya’s flagship digital health solution rolled out to strengthen community health service delivery and accelerate progress towards achieving universal health coverage. Despite its widespread rollout, evid...

The burden of bladder cancer in Africa: a 2024 GLOBOCAN-based study with projections to 2050

Abstract Background Bladder cancer is a significant global health concern with substantial variations in burden geographically. In Africa, distinctive epidemiology determines the pattern of incidence of bladder cancer in addition to typical risk factors and given the evolving dem...

Spatiotemporal patterns of antimicrobial resistance in shared human-animal waterpoints in the Maasai Mara Ecosystem, Kenya

Antimicrobial resistance (AMR) presents an existential One Health threat. The spread of AMR in arid and semi-arid landscapes is modulated by ecological interactions and exacerbated by endemicity of livestock diseases and poor sanitation in shared human-animal systems leading to m...

A User-Centered Approach to Customizing, Validating, and Evaluating a Large Language Model for Empowering Healthcare Providers with Up-to-Date Information on Adolescent and Child Health

Healthcare professionals (HCPs) in Kenya face critical challenges in accessing reliable, context-specific information on adolescent and child health, which hampers clinical decision-making and compromises patient outcomes. Large Language Models (LLMs) offer a promising solution b...

The Framework for Policy Decision on the RTS,S/AS01 malaria vaccine: the use of emerging data to inform global policy on the first malaria vaccine

The World Health Organization (WHO)-coordinated Malaria Vaccine Implementation Programme (MVIP) supported pilot introductions of the RTS,S/AS01 malaria vaccine by the ministries of health through the childhood immunization programmes in Ghana, Kenya and Malawi from 2019 through 2...

Maternal healthcare quality, continuity, and experiences among pregnant adolescents and adult women in Ethiopia, Kenya, and South Africa: A cohort study

The capacity of health systems to provide quality care for pregnant adolescents remains underexplored. This study examined the quality, continuity, and experiences of maternal healthcare among pregnant adolescents (<20 years) compared with adult women (20 + years) in Ethiopia, Ke...

Performance evaluation of validated diagnostic assays for Rift Valley Fever: a systematic review

Accurate diagnosis of Rift Valley Fever (RVF) disease is critical for outbreak surveillance, containment, intervention, trade, and public health. In this study, we sought to review available evidence on characteristics of validated RVF diagnostic assays used in livestock, humans...

One-year outcomes and intervention waiting time of patients admitted with congenital heart disease at Kenyatta National Hospital, Kenya

Congenital Heart diseases (CHD) are clinically significant structural heart disease present at birth. CHD is found in 8–15 babies per 1,000 live births. Delayed diagnosis and long waiting time to intervention may lead to poor outcome. The objective was to establish the one-year p...

Evaluating farmers’ knowledge, attitudes and adaptation practices of seasonal weather forecasts in semi-arid South Eastern Kenya

Considerable national and county-level efforts have been devoted to incorporating weather and climate information services (WCIS) into development planning in Kenya. However, farmers' understanding of these services remains largely unexplored. This study evaluates farmers' knowle...

Prevalence and determinants of death registration across three demographic surveillance sites in Kenya

Abstract Background Death registration remains markedly incomplete in many low- and middle-income settings despite its importance in generating population statistics for health systems planning and monitoring of sustainable development goals. We assessed the completeness of death...

Equity in digital palliative care: a scoping review of disparities and facilitators

Digital health technologies offer significant potential to enhance palliative care delivery but concerns persist regarding equitable access across diverse populations. This scoping review maps the existing literature on digital palliative care interventions, identifies barriers a...

Prevalence of meeting aerobic physical activity and resistance training guidelines in advanced prostate cancer: a descriptive study of racial and regional disparities in the IRONMAN registry

Abstract Purpose To estimate guideline-based aerobic physical activity and resistance training participation in an international population of people with newly diagnosed metastatic hormone-sensitive or castration-resistant prostate cancer, and to assess racial and regional diffe...

Machine Learning Modelling of Mental Disorders in the People of South Sudan

The increase in mental health challenges among the population has raised serious concerns among educators, healthcare professionals, and lawmakers. Because of the substantial impact of mental diseases on emotions, cognition, and social relationships, creative preventative and int...

Leveraging community health workers for the promotion of Breast Cancer Awareness and Timely Help-Seeking Behaviour (BreCATH-B study), among underserved rural population in Kenya: a protocol for a hybrid type II cluster randomised controlled trial

Female breast cancer (FBC) is the world’s most diagnosed cancer and the leading or second leading cause of female cancer-related deaths in 95% of the countries. In Kenya, it is the most diagnosed cancer with 7, 243 (16.2%) new cases reported in 2023. Advanced-stage FBC diagnosis...

An Fc receptor and IgA functional signature identifies TB disease in children living with HIV

Abstract Background Tuberculosis (TB) is a leading cause of morbidity and mortality among children living with HIV (CLHIV). TB disease is difficult to detect with current clinical microbiological, immunological, and radiographic tools. Serological assays that determine levels of...