University of Nagasaki

Identification of the Down Syndrome Critical Region 3 Gene as a Mammalian Cell Size Regulator

Using a genetic screening approach based on an inducible gene-activating system and cell sorting, Down syndrome critical region 3 (DSCR3) was isolated as a gene whose overexpression increased cell size. Fibroblasts derived from individuals with Down syndrome (DS) exhibit elevated...

The potential modulating role of thyroid cysts on the association between anti–thyroid peroxidase antibodies and subclinical hypothyroidism

Abstract Background In our previous study, the absence of thyroid cysts was identified as an indicator of thyroid functional strain associated with thyroid peroxidase antibody (TPO-Ab) positivity. In individuals under this continuous functional load, higher levels of thyroid-stim...

Synergistic Ag/In Co-doping-Induced Band and InterfaceEngineering in p-Type CuSe on Carbon Fabric for a FlexibleThermoelectric Generator

Abstract In the present work, a dual-doping strategy with silver (Ag) and indium (In) in copper selenide (CuSe) nanoparticles on conductive carbon fabric (CF) has been employed with a facile hydrothermal technique. This co-doping strategy outperforms single-element doping by enab...

Rheumatoid arthritis-associated peptidylarginine deiminase 4 haplotype citrullinates human immunodeficiency virus-pol and confers antiviral activity

Peptidylarginine deiminase 4 (PADI4)-mediated citrullination modulates immune responses and drives autoantibody formation in rheumatoid arthritis (RA). Two common haplotypes, defined by four exonic SNPs ( PADI4_89 , 90 , 92 , and 104 ), have been described, with haplotype 2 (the...