University of Minnesota Medical Center

Development and Validation of a Coronary Artery Calcium Volume and Density Score

BACKGROUND: Coronary artery calcium (CAC) scoring is a useful tool for coronary heart disease (CHD) risk prediction. The current standard method, the Agatston score, weights plaque area upward by density. However, higher density is inversely associated with CHD. We aimed to devel...

Long-term outcomes and treatment cessation in patients with long term response to first line treatment of metastatic prostate cancer

Abstract Background and objective Approximately one third of men with metastatic prostate cancer die from causes other than prostate cancer. Little is known about the long-term outcomes of men with metastatic prostate cancer, in particular those who do not develop androgen pathwa...

Unique challenges, unique solutions: end-user designed strategies to improve PTSD treatment initiation in U.S. Special Operations Forces

Abstract Background Despite the effectiveness of evidence-based psychotherapies for posttraumatic stress disorder (PTSD), uptake of treatment remains particularly challenging for some subgroups at high risk for PTSD. United States (U.S.) Special Operations Forces (SOF) Operators/...

Bridging the data latency gap: automated extraction of genomic biomarkers from unstructured clinical documents to support real-world oncology data

Abstract Purpose Real-world oncology data are essential for clinical research and precision cancer care. However, genomic biomarkers are often embedded in scanned, unstructured clinical documents requiring manual abstraction before becoming available in cancer registries, delayin...

Genomic and Transcriptomic Correlates of Deep PSA Response in Patients with Metastatic Androgen Pathway Modulation-Sensitive Prostate Cancer

Abstract Background Despite advances in metastatic androgen pathway modulation-sensitive prostate cancer (mAPMS) treatment, outcomes remain heterogeneous. Achieving a post-treatment undetectable prostate specific antigen (PSA) is a strong prognostic marker. We aimed to identify g...

Sex & Gender Science: integrating the social with the biological

Abstract For decades, researchers have largely studied aspects of sex and gender separately; the former as a basic science and the latter as a social construct with real world consequences, including health inequities. In recent years, as our collective understanding of how the b...

Moderators of the Effects of Telehealth Mindfulness-based Interventions for Chronic Pain

OBJECTIVES: Little is known about who benefits most from Mindfulness-Based Interventions (MBIs), and whether certain groups differentially benefit from different types of MBI formats (group-based versus non-group based). The present study uses data from a three-arm randomized con...

Burden and Risk Factors for Severe Respiratory Syncytial Virus Infection Among Pediatric Hematopoietic Cell Transplant Recipients

BACKGROUND: Respiratory syncytial virus (RSV) causes substantial morbidity in pediatric hematopoietic cell transplant (HCT) recipients; however, risk factors for severe disease remain incompletely characterized. METHODS: We conducted a multicenter retrospective cohort study acros...

Treatment of Congenital Cytomegalovirus Beyond the Neonatal Period: A Single‐Arm Meta‐Analysis

ABSTRACT Objective To evaluate hearing outcomes in postneonatal treatment of congenital cytomegalovirus (cCMV) infection and assess the effect of treatment initiated after the first month of life. Data Sources PubMed, Embase, Web of Science, and Cochrane Library were systematical...

Decision Analysis to Inform Screening of the Young: An Interactive Newborn Screening Model

Decision analytic models that project the outcomes of population-based newborn screening compared with clinical identification can inform newborn screening policymaking. A flexible decision analytic model that could be adapted for the many and growing number of conditions being c...

Histoplasmosis in Pregnancy: A Review and Patient Perspective

Abstract Histoplasmosis is rarely diagnosed in pregnancy, though when disseminated it may infect the infant as well. Decisions regarding antifungal therapy in pregnant women can be difficult due to known toxicity risks and lack of rigorous study. Here we review the published lite...

Navigating physician-scientist careers: insights from American Board of Internal Medicine Research Pathway graduates

The American Board of Internal Medicine Research Pathway (ABIM RP) is designed to train physician-scientists by shortening postgraduate clinical training and increasing research time. We surveyed ABIM RP graduates to understand career trajectories, research engagement, and barrie...

Changes in resting-state functional connectivity between large-scale brain networks after an intensive arts intervention for adolescents with depression

Emerging data support the benefits of creative arts interventions for addressing depression in adolescents, but the neural mechanisms are poorly understood. This study examined changes in connectivity among large-scale brain networks implicated in both depression and creativity,...

Tackling anti-tumor macrophage function through genome engineering

In the realm of cellular immunotherapies, the synthetic chimeric antigen receptor (CAR) has proven to be a revolutionary modality, leading to the US Food and Drug Administration approval of multiple autologous CAR T cell products. Despite their remarkable success in hematological...

Longitudinal evaluation of sleep disturbances in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study

Abstract Purpose The current study examines longitudinal changes in sleep disturbances and the risks they pose for new-onset health conditions in survivors of childhood cancer. Methods Five-year survivors ( N = 1081; median [range] age 50.0 [45.2–55.0] years) and siblings ( N = 2...

Femoral Rotation Osteotomy in Patellofemoral Instability Surgery

Femoral anteversion is an important anatomic risk factor for patellofemoral instability. History and physical exam, in addition to diagnostic imaging, are all components of a full assessment to determine whether femoral anteversion is a significant contributor to a patient's pate...

Adapting Maslow’s Hierarchy of Needs to a student advising framework

Abstract This AM Last Pages describes how Maslow’s Hierarchy can help students understand the myriad of tasks they must complete from a career perspective in medical school. These 5 distinct tasks include finishing medical school intact, meeting minimum standards to finish school...