University of Miami Health System

Cutaneous phaeohyphomycosis with the recently described fungus Gloniopsis leucaenae: first case report

Abstract Background Fungi of genus Gloniopsis are plant pathogens within class Dothideomycetes, rarely described to cause human infection. Species Gloniopsis leucaenae ( G. leucaenae ) was first isolated in 2019 and previously reported only in plant matter in Thailand. Case prese...

Aspergillus Endophthalmitis: Clinical Features, Treatment Modalities, and Visual Outcomes

Purpose: The purpose of this study was to evaluate clinical features, treatment modalities, and visual outcomes of Aspergillus endophthalmitis in a tertiary referral center. Methods: This was a retrospective consecutive case series of patients with Aspergillus endophthalmitis tre...

Mechanical Loading Reshapes Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicle microRNA Cargo Toward Predicted Immunomodulatory and EV Cargo-Trafficking Pathways: An In Vitro Mechanobiology Study

Mesenchymal stem/stromal cell-derived extracellular vesicles (MSC-EVs) are emerging as cell-free therapeutic candidates for osteoarthritis, but most approaches treat the secretome as a passively collected product rather than a tunable biologic. Because joint loading regulates car...

Healthcare providers’ perceptions and prescribing behaviors of short-term prevention treatment of migraine in the United States

AIMS: Short-term prevention (STP) therapies are used to prevent migraine during anticipated exposure to known triggers. However, little is known about healthcare providers' (HCPs) attitudes and prescribing practices regarding STP. This study aimed to characterize real-world STP t...

BUB1B Mitotic Kinase Dependency Reveals CENP-E Inhibition as a Tractable Approach for Castration and Enzalutamide Resistant Prostate Cancer

Abstract Castration-resistant prostate cancer (CRPC) progression despite treatment with potent androgen receptor (AR) antagonists such as enzalutamide is a major clinical challenge. The mitotic kinase BUB1B is a central member of an oncogenic seven-gene network that drives CRPC....

Superlarge-Bore Versus Large-Bore Aspiration Catheters in Mechanical Thrombectomy: A Multicenter Propensity-Matched Analysis

BACKGROUND AND OBJECTIVES: Aspiration catheters are an integral component of mechanical thrombectomy for acute ischemic stroke (AIS). Following early series demonstrating increasing procedural efficiency and improved outcomes with use of large-bore (LB) aspiration catheters, ther...

Mistreatment during facility-based childbirth in Benin City, Nigeria: A convergent mixed-methods study of prevalence and drivers

Abstract Background Mistreatment during facility-based childbirth undermines maternal health outcomes and trust in health systems, particularly in low- and middle-income countries. Nigeria bears one of the highest global burdens of maternal mortality, yet limited large-scale mixe...

Optimal Data Collection in Lifestyle Medicine at the Point of Care: A Position Statement From the American College of Lifestyle Medicine

The full potential of lifestyle medicine has yet to be realized within the healthcare system, and it is hindered by the lack of systematic data collection focused on modifiable lifestyle factors that influence chronic disease. It is the position of the American College of Lifesty...