University of Medicine and Pharmacy of Craiova

Circulating Zonulin in Irritable Bowel Syndrome: A Systematic Review of Conflicting Evidence and the Critical Impact of Assay Specificity

Background: Increased intestinal permeability is a proposed pathophysiological mechanism in irritable bowel syndrome (IBS), and zonulin, a putative regulator of tight junctions, has been investigated as a non-invasive serum biomarker. However, the diagnostic utility of circulatin...

Sinus Floor Elevation Magnitude and Longitudinal Peri-Implant Marginal Bone Change over a Minimum Five-Year Follow-Up: A Retrospective Cohort Study

Background/Objectives: The magnitude of maxillary sinus floor elevation may reflect site anatomy and surgical complexity, but its association with peri-implant marginal bone change remains unclear. This study evaluated whether elevation magnitude was associated with longitudinal...

Residual Deep Learning for Realized Volatility Using a Hybrid HAR-LSTM Model with ARIMA Features and SHAP Interpretability

Classical linear models such as the Heterogeneous Autoregressive Realized Volatility (HAR-RV) model are difficult to beat at short horizons, yet cannot capture nonlinear, regime-dependent dynamics, while pure deep learning approaches typically overfit. This paper proposes a resid...

Adjunctive Low-Level Laser Therapy and Deep Oscillation in Pulmonary Rehabilitation for Post-Tuberculosis Lung Disease

Background: Post-tuberculosis lung disease (PTLD) is associated with persistent functional impairment and reduced quality of life. This study evaluated the association between the addition of low-level laser therapy (LLLT) and deep oscillation (DO) to structured pulmonary rehabil...

Traumatic Intracranial Vascular Lesions in Adults Undergoing Vascular Imaging After Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Background and Objectives: Traumatic intracranial vascular lesions are rare but severe complications of traumatic brain injury (TBI) and include arterial and venous injuries such as arterial dissections, pseudoaneurysms, arterial occlusions, venous sinus thrombosis, arteriovenous...

Diagnostic Performance of Diffusion-Weighted MRI and ADC Values in Differentiating Atypical Leiomyomas from Uterine Sarcomas.

BACKGROUND: Leiomyomas are the most common benign uterine tumors, whereas uterine sarcomas are rare malignant neoplasms associated with high morbidity and mortality. Differentiation using imaging remains challenging because of overlapping radiologic features. PURPOSE: To evaluate...

The Influence of Ageing, Sex and Cause of Death on the Myocardial Tissue Collagen Fibrillary Component Behaviour.

AIM: The morphology and the function of human body are influenced by two main factors: the passing of the years and the increasing diversity of diseases with their subsequent lesions. The morphological structures of the heart are not exempt from the synergistic influence of these...

From Data to Decision: Interpretable and Reliable Heart Disease Risk Prediction.

BACKGROUND: Heart disease is the leading cause of morbidity and mortality worldwide, highlighting the need for accurate and clinically meaningful risk prediction tool. METHODOLOGY: A retrospective analysis was performed on a dataset of 918 patients with complete clinical informat...

Clinicopathological Features and Statistical Associations in Squamous Cell Carcinoma of the Lip.

BACKGROUND: Lip squamous cell carcinoma (SCC) is frequently associated with chronic ultraviolet exposure and actinic cheilitis. Although prognosis is generally favorable, clinicopathological parameters may correlate with tumor characteristics and risk-related patterns. MATERIALS...

The Assessment of T-Lymphocytes In Gastric Adenocarcinomas.

Gastric adenocarcinomas (GAC) are common cancers in pathology, which pose real problems in practice due to heterogeneity, response to treatment and prognosis. New therapeutic approaches in GAC are aimed at activating the immune system by unblocking or modulating it. In this study...

Sex-Related Differences in Clinical Characteristics and Outcomes Among Patients Clinically Managed for Suspected Bacterial Infection in the Emergency Department

Background and Objectives: Suspected bacterial infection is one of the leading presentations to the Emergency Department (ED) and is still associated with considerable morbidity and mortality. There is increasing evidence that biological sex may influence host immune responses, d...

Is routine terminal ileum intubation justified during screening colonoscopy? Evidence from a regional screening program.

Background∕Aim: Although colonoscopy represents the cornerstone of colorectal cancer (CRC) screening, the incremental diagnostic yield of routine terminal ileum (TI) intubation remains insufficiently defined, particularly in fecal immunochemical test (FIT) positive patients. This...

Clinical and Epidemiological Characteristics of Retrospective Single-Center Observational Study

Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe adverse event associated with antiresorptive therapy, particularly bisphosphonates, and represents a significant challenge in oral and maxillofacial practice. This study aimed to characterize the epid...

Study-Specific Morphological Signs of Non-Carious Tooth Surface Loss in Second Permanent Molars and Caries Experience in a Clinical Sample of Adolescents from Southwest Romania: A Multicenter Cross-Sectional Study

Background/Objectives: Morphological signs of non-carious tooth surface loss are clinically heterogeneous, and their prevalence depends strongly on the diagnostic framework and threshold used. This exploratory secondary analysis evaluated a study-specific combined morphological o...

Ultrasound-Guided Collagen Peptides Injections Combined with Focused Extracorporeal Shockwave Therapy and Therapeutic Exercise in Chronic Partial Common Extensor Tendon Tears at Elbow Lateral Epicondyle: A Retrospective Case Series

Background: Lateral elbow tendinopathy (LET) is a common upper-limb musculoskeletal disorder causing pain during gripping activities, reduced work capacity, and functional limitation. LET is currently considered a predominantly degenerative condition characterized by collagen dis...

Spermatocytic Tumor Arising in a Cryptorchid Testis: A Case Report and Narrative Review

Background: Spermatocytic tumor (ST) is a rare non-GCNIS-derived testicular germ cell neoplasm that predominantly affects older men and generally follows an indolent course. Its occurrence in a cryptorchid testis is exceptionally uncommon. Methods: A narrative literature review w...

Recent Advances in Biomarkers of Systemic Sclerosis-Associated Interstitial Lung Disease: Clinical Relevance and Therapeutic Perspectives

Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is the leading cause of mortality in patients with systemic sclerosis and a major clinical challenge due to its heterogeneous presentation and variable disease course. Reliable biomarkers may improve disease assess...

Bilateral-Asymmetry-Aware Multiple-Instance Learning for Breast Cancer Classification on Chest CT

Incidental breast abnormalities may be visible on chest computed tomography (CT), although breast tissue is frequently outside the primary diagnostic focus of these examinations. This proof-of-concept study developed and internally evaluated a bilateral-asymmetry-aware multiple-i...

Changes in Patient Attitudes and Vaccination Intention After Pneumococcal Vaccination Counselling by Trained Family Physicians: A Multicentre Implementation Study in Romania

Introduction: Improving adult pneumococcal vaccination is a public-health priority in Romania, and evidence regarding patient-level outcomes following different approaches to physician training remains limited. Materials and methods: This non-randomised, multicentre, quasi-experi...

Surgical Complexity and Postoperative Outcomes in Recurrent Versus Primary Incisional Hernias Following Elective Retromuscular Repair: A Retrospective Cohort Study

Background/Objectives: Recurrent incisional hernia remains a major challenge in abdominal wall surgery and is frequently associated with increased surgical complexity and adverse outcomes. However, its role as a distinct surgical entity and its cumulative operative impact remain...